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This medication comes with important safety information that you should review carefully. If you have any questions or concerns, please consult your healthcare provider.

• Orthostatic Hypotension: When you first start taking doxazosin (Cardura) or if your dosage is increased, you may experience a sudden drop in blood pressure upon standing, known as orthostatic hypotension. Be cautious when changing positions from sitting or lying down to standing. Symptoms may include dizziness, lightheadedness, blurred vision, fainting, nausea, and confusion. Your body may adjust within a few days, but if symptoms persist, contact your healthcare provider. Seek immediate medical attention if you fall and hit your head. Risk factors include rapid position changes, dehydration, concurrent use of blood pressure-lowering medications, heart failure, alcohol consumption, and older age.

• Prolonged Erection: On rare occasions, doxazosin (Cardura) may cause a prolonged and painful erection, known as priapism, which can require surgical intervention. If you experience an erection lasting longer than four hours, discontinue use and seek medical help immediately.

• Eye Issues: Doxazosin (Cardura) can lead to a condition called intraoperative floppy iris syndrome (IFIS) during cataract surgery, which increases the risk of eye complications. This condition may occur even if the medication has been discontinued. Inform your eye surgeon if you are taking doxazosin (Cardura), as they may need to adjust your treatment or surgical approach to reduce risk. Risk: Scheduled cataract surgery.

• Digestive System Concerns (Cardura XL only): Although uncommon, there have been reports of gastrointestinal blockages in patients using extended-release forms similar to Cardura XL (doxazosin). If you experience symptoms such as bloating, severe stomach pain, nausea, or vomiting, contact your healthcare provider. Risk factors include a history of digestive issues.

Please ensure you follow your healthcare provider's instructions and report any concerning symptoms or side effects.

Common side effects:

• dizziness
• fatigue
• headache
• respiratory tract infections

• unusually tired or weak

  Less common but important to monitor:

• swelling of the hands or feet

• sore throat that does not go away

  Serious side effects:

• chest pain
• shortness of breath
• fainting
• severe allergic reaction (rash, itching, swelling of the face, tongue, or throat)
• painful or prolonged erection lasting four or more hours

Interactions with high risk of serious adverse effects and should be avoided:

• Boceprevir

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Alfuzosin
• Asenapine
• Silodosin
• Tamsulosin
• Acebutolol
• Atenolol
• Bisoprolol
• Sildenafil
• Tadalafil
• Vardenafil

Interactions with low risk that usually do not require a change in therapy:

• Itraconazole
• Ketoconazole
• Clarithromycin
• Lopinavir
• Ritonavir
• Cough-and-cold products
• Diet aids
• NSAIDs (e.g., ibuprofen, naproxen)