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Droxidopa

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generic Northera

Droxidopa, also known as Northera, is prescribed for adults experiencing neurogenic orthostatic hypotension (nOH), a condition characterized by low blood pressure when standing, often due to specific neurological disorders like multiple system atrophy, pure autonomic failure, or Parkinson's disease. This medication is particularly beneficial for individuals whose daily activities are significantly impaired by nOH, even after other treatments, such as support stockings or increased fluid intake, have been tried. Droxidopa functions by converting into norepinephrine in the body, a hormone that constricts blood vessels, thereby elevating blood pressure. This process helps alleviate symptoms such as dizziness, lightheadedness, or a sensation of imminent fainting. The medication is typically taken orally three times a day, with the last dose administered at least three hours before bedtime to minimize the risk of elevated blood pressure while lying down, which can lead to serious complications like heart issues or stroke. Users may experience side effects such as headaches and dizziness. As with any medication, it is crucial to consult with a healthcare provider before starting droxidopa to ensure it is appropriate and safe based on individual health needs.
Our coupons are free to use. Before paying, show the pharmacist your Droxidopa savings card to get your free discount. Use our filters below to edit the prescription box to match your needs. The Droxidopa prices will update based on your prescription needs. Above our Droxidopa coupons, you can change your location to see pharmacy prices and costs in other areas. We're here to help you buy Droxidopa at the lowest price with our prescription discount card.

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100MG, Droxidopa (30 Capsules)

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Rite Aid

$27.06

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$45.52

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$252.03

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Droxidopa dosage forms

The average cost for 30 Capsules of Droxidopa (generic Northera) at 100MG is $23.64 with a free coupon. This is 2.19% off the average retail price of $1078.8
DosageQuantityPrice fromPer unit
100MG30 Capsules$23.64$0.79
200MG30 Capsules$43.74$1.46
300MG30 Capsules$72.34$2.41

Droxidopa Warnings

This medication, droxidopa (Northera), comes with several important safety precautions and risks that should be carefully considered. Please review these warnings and consult your healthcare provider if you have any concerns or questions.

  • Supine Hypertension: This medication can lead to a significant increase in blood pressure when you are lying down. To minimize this risk, avoid taking droxidopa while lying down and consider elevating the head of your bed. Your healthcare provider will monitor your blood pressure in this position, especially after any dosage changes. If supine hypertension cannot be controlled, it may lead to serious health issues such as stroke, heart attack, or even death. In such cases, your doctor may adjust or discontinue the medication.

  • Neuroleptic Malignant Syndrome-like Symptoms: Rarely, individuals taking droxidopa may experience symptoms similar to neuroleptic malignant syndrome, which include high fever, muscle rigidity, involuntary movements, and confusion. These symptoms should be closely monitored, especially after a change in dosage. Seek immediate medical attention if these symptoms occur.

  • Heart Conditions: Droxidopa may exacerbate certain heart conditions, such as heart disease, heart failure, and heart rhythm irregularities. It is crucial to inform your healthcare provider of any existing heart conditions before starting treatment with this medication.

  • Severe Allergic Reactions: Allergic reactions to droxidopa can occur, with some being life-threatening, such as anaphylaxis. Additionally, some formulations of droxidopa contain Yellow No. 5 (tartrazine), which can cause respiratory issues in susceptible individuals. If you experience symptoms like a rash, difficulty breathing, or swelling of the face, tongue, or throat, seek medical help immediately.

Always discuss any pre-existing conditions and your complete medical history with your healthcare provider before starting treatment with droxidopa. In case of an overdose or severe reaction, seek emergency medical assistance promptly.

Droxidopa Side Effects

Common side effects:

  • headaches
  • dizziness
  • nausea

Less common but important to monitor:

  • vomiting
  • diarrhea
  • stomach pain
  • chest pain
  • tiredness
  • blurred vision

Serious side effects:

  • rash
  • itching
  • swelling of the face, tongue, or throat
  • trouble breathing
  • neuroleptic malignant syndrome (NMS)
Droxidopa FAQs
Is droxidopa better than midodrine?

The choice between droxidopa and midodrine depends on the specific medical condition being treated and the individual patient's response to the medication. Both are used to treat orthostatic hypotension, but they work through different mechanisms. Droxidopa is a norepinephrine precursor, while midodrine is an alpha-1 adrenergic agonist. The effectiveness and side effects can vary between individuals, so a healthcare provider would consider the patient's specific situation, including any underlying conditions and response to previous treatments, before determining which medication might be more suitable.

Droxidopa is used to treat orthostatic hypotension, a condition characterized by a significant drop in blood pressure when standing up, which can lead to dizziness or lightheadedness. It is often prescribed for patients with conditions such as Parkinson's disease, multiple system atrophy, or pure autonomic failure.

Droxidopa works by being converted into norepinephrine, a neurotransmitter that helps to increase blood pressure. In patients with orthostatic hypotension, droxidopa helps to improve blood flow and reduce symptoms like dizziness and lightheadedness when standing up.

The best drug for treating orthostatic hypotension often depends on the underlying cause and the patient's overall health. However, fludrocortisone is commonly used as it helps increase blood volume. Midodrine is another medication frequently prescribed, as it works by constricting blood vessels to raise blood pressure. It is important for a healthcare provider to evaluate the specific needs of the patient to determine the most appropriate treatment.

Droxidopa is not classified as a controlled substance. It is a medication used to treat certain conditions, but it does not fall under the controlled substances category.