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The information below outlines important safety considerations and potential risks associated with the use of epinephrine (Adrenalin). It is crucial to discuss any concerns with your healthcare provider.

• Increased Blood Pressure and Heart Rate: Epinephrine may elevate blood pressure and heart rate. Healthcare providers will monitor these vital signs closely and adjust dosage if necessary. Notify your provider immediately if you experience difficulty breathing, chest pain, dizziness, visual changes, or headaches, as these may indicate excessive blood pressure or heart rate. This risk is higher with intravenous administration, excessive dosing, a history of heart issues, or concurrent use of medications affecting heart rate or blood pressure.

• Tissue Damage (Infusion Only): Rarely, epinephrine infusions may leak into surrounding tissues, potentially causing skin damage. Regular monitoring of the injection site is necessary. Report any pain, warmth, swelling, tenderness, or redness to your healthcare team promptly. If tissue damage occurs, the infusion site may need to be changed, and an antidote, such as phenotolamine, might be administered.

• Fluid Accumulation in the Lungs (Infusion Only): Epinephrine infusion can lead to fluid buildup in the lungs, causing breathing difficulties or discomfort. Inform your provider immediately if you notice any changes in breathing. Treatment may include phenotolamine and additional breathing support.

• Kidney Function Impairment (Infusion Only): Epinephrine may reduce kidney blood flow, potentially damaging kidney function and affecting urine production. Providers will monitor kidney health and adjust treatment as needed.

• Infection Risk at Injection Site: Although rare, infections at the injection site have been reported following epinephrine administration for anaphylaxis. Alert your healthcare team if you observe any signs of infection such as redness, warmth, swelling, or tenderness at the injection site.

• Sulfite Sensitivity: Epinephrine contains a sulfite preservative, which may trigger allergic reactions in sensitive individuals. Seek immediate medical attention if you experience hives, rash, skin redness, swelling of the lips or tongue, or breathing difficulties. This is particularly important for those with a known sulfite allergy.

Please consult your healthcare provider for any further information or clarification needed regarding these warnings.

When taking this medication, some individuals may experience common side effects, which are typically mild. These include feelings of anxiety, restlessness, trembling, weakness, dizziness, sweating, a pounding heart, nausea or vomiting, headaches, and looking pale. While these symptoms are usually not serious, if they persist or worsen, it is advisable to consult a healthcare provider for guidance.

There are also other side effects that have been reported by some users. These may include a high heart rate, irregular heart rhythm, elevated blood pressure, chest pain, kidney issues, and breathing difficulties. If you experience any of these, particularly if they are severe, it is important to contact your healthcare provider promptly.

In rare cases, serious side effects can occur, which necessitate immediate medical attention. These include significantly high blood pressure, marked by headaches, chest pain, dizziness, or blurry vision. Irregular heart rhythms can manifest as fatigue, weakness, shortness of breath, or chest pain. Skin problems like pain, warmth, or redness at the injection site, and excess fluid in the lungs causing breathing difficulties, may also occur. Additionally, severe allergic reactions marked by hives, swelling of the lips or tongue, or difficulty breathing require urgent care. Lastly, kidney issues such as low urine output or muscle cramps should not be overlooked. If any of these serious symptoms arise, seek emergency medical help without delay.