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Midodrine

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Midodrine is prescribed for individuals experiencing symptoms of orthostatic hypotension, a condition characterized by low blood pressure upon standing. This medication is particularly beneficial for patients whose daily lives are significantly impacted by this condition, even after trying other treatments like support stockings. Midodrine functions as an alpha-1 adrenergic receptor agonist, a type of sympathomimetic that works by constricting blood vessels to elevate blood pressure. It is important to take this medication only when upright, as it can dangerously increase blood pressure while lying down. Some users may experience side effects such as a tingling sensation or goosebumps. Midodrine is available in a generic form, with no brand-name equivalent. Always consult your healthcare provider to ensure this treatment is appropriate for you.
Our coupons are free to use. Before paying, show the pharmacist your Midodrine savings card to get your free discount. Use our filters below to edit the prescription box to match your needs. The Midodrine prices will update based on your prescription needs. Above our Midodrine coupons, you can change your location to see pharmacy prices and costs in other areas. We're here to help you buy Midodrine at the lowest price with our prescription discount card.

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10MG, Midodrine (30 Tablets)

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$20.70

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$9.64

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$11.49

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$66.16

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Midodrine dosage forms

The average cost for 30 Tablets of Midodrine at 10MG is $11.49 with a free coupon. This is 22.66% off the average retail price of $50.7
DosageQuantityPrice fromPer unit
10MG30 Tablets$11.49$0.38

Midodrine Warnings

Midodrine is a medication that requires careful consideration before use due to its significant impact on blood pressure and potential interactions with other health conditions. Below are important safety warnings and guidelines to ensure its safe administration:

  • Blood Pressure Increase When Lying Down: Midodrine can significantly elevate blood pressure when you are lying down. This can be dangerous, leading to blood pressure levels above 200 mmHg. Therefore, avoid taking midodrine if you are planning to lie down. It should only be used if orthostatic hypotension severely impacts your daily activities and other treatments have not been effective. Alert your healthcare provider if you experience a rapid heartbeat, pounding in the ears, headaches, or blurred vision after taking midodrine in a lying position. Discontinue use if these symptoms persist.

  • Slow Heart Rate: This medication may reduce your heart rate. Discuss with your healthcare provider before starting if you are on other medications that also lower heart rate, such as digoxin, beta blockers, or certain antidepressants. Report any symptoms like a slow pulse, dizziness, faintness, or irregular heartbeat to your provider.

  • Pre-existing Health Conditions: Since midodrine constricts blood vessels, it may exacerbate certain medical conditions. Those with existing urination difficulties may experience worsening symptoms, as midodrine affects blood vessels in the bladder neck. It can also impact eye health, particularly in diabetic patients or those with a history of eye issues, especially if taking fludrocortisone, which can increase eye pressure and risk of glaucoma. Patients with kidney or liver problems should also exercise caution.

  • Contraindications: Midodrine should not be used in individuals with severe heart conditions, sudden onset kidney problems, urinary retention, pheochromocytoma (a rare adrenal gland tumor), thyrotoxicosis (excess thyroid hormone), or those who frequently experience high blood pressure when lying down. Consult with your healthcare provider if any of these conditions apply.

Always discuss any concerns or symptoms with your healthcare provider to ensure the safe use of midodrine. In case of an overdose or severe adverse reaction, seek emergency medical assistance immediately.

Midodrine Side Effects

Common side effects:

  • Tingling sensation in the skin
  • Chills
  • Goosebumps
  • Stomach pain
  • Strong urge to urinate
  • Frequent urination
  • Difficulty urinating

Less common but important to monitor:

  • Dry mouth
  • Dizziness
  • Drowsiness
  • Trouble sleeping
  • Leg cramps
  • Supine hypertension
  • Pounding heartbeat
  • Pounding in the ears
  • Headache
  • Blurred vision

Serious side effects:

  • Slow heartbeat
  • Unusual chest sensations
  • Fainting
  • Pressure or fullness in the head
  • Confusion
  • Anxiety
  • Weakness
  • Vision problems
  • Severe allergic reaction
  • Rash
  • Itching
  • Swelling (especially of the face, tongue, or throat)
  • Severe dizziness
  • Trouble breathing

Midodrine Interactions

Interactions with high risk of serious adverse effects and should be avoided:

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

Interactions with low risk that usually do not require a change in therapy:

Midodrine FAQs
What does the drug midodrine do?

Midodrine is a medication that is primarily used to treat orthostatic hypotension, a condition where a person's blood pressure drops significantly upon standing, leading to dizziness or fainting. It works by constricting blood vessels and increasing blood pressure, thereby helping to reduce symptoms associated with low blood pressure.

Midodrine is generally used to treat low blood pressure, and while it can be effective, it may have cardiovascular side effects. It can cause an increase in blood pressure, particularly when lying down, which might be a concern for some individuals with certain heart conditions. It is important for patients to discuss their medical history and any heart-related concerns with their healthcare provider before starting midodrine to ensure it is safe for their specific situation. Regular monitoring by a healthcare professional is recommended to manage any potential risks.

Midodrine should be stopped if the patient experiences severe or intolerable side effects, such as significant supine hypertension. It may also be discontinued if it is not effectively managing the symptoms it was prescribed for, or if the underlying condition has resolved. The decision to stop midodrine should always be made in consultation with a healthcare provider, who can assess the risks and benefits in the context of the patient's overall health condition.

Midodrine primarily acts as a vasopressor, which means it helps to increase blood pressure by causing blood vessels to constrict. It is not directly used to treat heart conditions but can indirectly support heart function by improving blood flow and maintaining adequate blood pressure, especially in conditions like orthostatic hypotension.

Midodrine is not typically classified as a high-risk medication, but it does require careful monitoring due to its potential side effects and interactions. It is important for patients to follow their healthcare provider's instructions closely and report any adverse effects. Regular follow-up appointments are recommended to ensure safe and effective use.