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This document outlines critical safety information and warnings for the use of epinephrine (Epipen). Please read the following points carefully and discuss any concerns with your healthcare provider.

• Immediate Medical Attention: After using epinephrine (Epipen), it is crucial to seek immediate medical assistance, even if your symptoms improve. Continuous monitoring by a healthcare professional is advised to manage any recurring symptoms or additional treatment needs. Remember, epinephrine (Epipen) is not a substitute for medical care.

• Proper Injection Method: Administer epinephrine (Epipen) exclusively by injection into the muscle or under the skin of the outer thigh. Avoid injecting it into any other body part or through any other route, as this could lead to serious medical complications.

• Risk of Skin Infection: Although rare, there is a potential for serious skin infections following the use of epinephrine (Epipen). To minimize this risk, do not inject the medication into the buttock area. Seek medical evaluation if the injection site shows signs of redness, warmth, swelling, or tenderness to test for and treat any potential infections.

• Sulfite Allergy Consideration: Epinephrine (Epipen) may contain sulfites. However, in instances of severe, life-threatening allergic reactions, it is vital to use epinephrine (Epipen) regardless of a sulfite allergy, as it is a life-saving intervention.

• Effects on Blood Pressure and Heart Rate: Epinephrine (Epipen) can increase blood pressure and heart rate. Notify your healthcare provider if you experience symptoms such as difficulty breathing, chest pain, dizziness, visual changes, or headaches, as these may indicate elevated blood pressure or heart rate, necessitating further medical treatment. The risk is heightened if epinephrine is administered intravenously, if there is a history of heart issues, or if you are taking medications that affect heart rate or blood pressure.

Please adhere to these guidelines to ensure safe and effective use of epinephrine (Epipen).

When taking this medication, some common side effects may occur but are typically mild. These include feelings of anxiety, nervousness, or restlessness, as well as shakiness, dizziness, sweating, and a racing heart. It's important to note that many people do not experience serious side effects, but if these symptoms persist or worsen, it's advisable to consult your healthcare provider.

Other side effects that might be experienced include pale skin, nausea or vomiting, headaches, and trouble breathing. Again, while these are generally not severe, seeking medical advice if they become bothersome is recommended.

There are also rare but serious side effects that require immediate medical attention. These include irregular heart rhythms, which may manifest as fatigue, weakness, dizziness, shortness of breath, chest pain, and sweating. High blood pressure can also occur, with symptoms such as headaches, chest pain, dizziness, and blurry vision. Additionally, a serious infection at the injection site could be indicated by persistent redness, tenderness, swelling, and warmth.

If you experience any of these severe side effects, it is crucial to seek urgent medical care. Always be vigilant and report any new or concerning symptoms to your healthcare provider for further guidance.