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This medication comes with important safety information that you should consider before starting treatment. Please review the following points and discuss any concerns with your healthcare provider:

• Increased Blood Pressure While Lying Down: This medication can cause a significant rise in blood pressure when you are lying flat. To minimize this risk, avoid taking the medication while lying down. Elevating the head of your bed can help manage this risk, but if high blood pressure persists, your doctor may need to adjust or discontinue the medication. Uncontrolled supine hypertension can lead to serious complications such as stroke or heart attack.

• Neuroleptic Malignant Syndrome-Like Symptoms: Rarely, this medication may cause symptoms resembling neuroleptic malignant syndrome (NMS), such as high fever, muscle stiffness, uncontrollable movements, and confusion. It is crucial to monitor for these symptoms, particularly when your dosage changes, and seek immediate medical attention if they occur.

• Exacerbation of Heart Conditions: Droxidopa (Northera) may aggravate existing heart conditions, including heart disease, heart failure, and arrhythmias. Inform your healthcare team about any heart issues you have before beginning treatment to assess your risk.

• Severe Allergic Reactions: There is a possibility of experiencing a severe allergic reaction to this medication, including anaphylaxis, which can be life-threatening. Some formulations contain Yellow No. 5 (tartrazine), which may cause breathing difficulties in sensitive individuals. Seek urgent medical attention if you develop a rash, difficulty breathing, or swelling of the face, tongue, or throat.

Always consult with your healthcare provider to ensure this medication is safe for you, particularly if you have any pre-existing conditions or are taking other medications. In case of an overdose or severe side effects, seek immediate medical assistance.

When taking this medication, some individuals may experience common side effects such as headaches, dizziness, nausea, or elevated blood pressure. These symptoms are generally mild and often subside on their own. However, if they persist or worsen, it is advisable to consult a healthcare professional. To minimize dizziness and lightheadedness, try to rise slowly from seated or lying positions.

Other side effects that have been reported include vomiting, diarrhea, stomach pain, chest pain, tiredness, and blurred vision. While these are less common, it's important to discuss any new or worsening symptoms with your healthcare provider to ensure your safety and well-being.

There are rare but serious side effects that require immediate medical attention. These include severe allergic reactions characterized by hives, swelling, or breathing difficulties; significantly high blood pressure when lying down, which may present as changes in heartbeat, pounding in the ears, or blurred vision; and symptoms resembling neuroleptic malignant syndrome (NMS), such as high fever, confusion, muscle rigidity, and irregular heartbeat. Prompt medical care is crucial if any of these severe symptoms occur. Always communicate any side effects you experience to your healthcare provider for appropriate guidance and support.