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The following safety information highlights important warnings associated with the use of Duobrii (halobetasol / tazarotene). It is crucial to understand these risks and precautions. Please consult your healthcare provider if you have any concerns or need further clarification.

• Pregnancy Risks: Duobrii may cause harm to an unborn baby, including developmental issues. It should not be used during pregnancy. Women who are able to conceive must undergo a pregnancy test two weeks prior to starting the treatment and should begin the medication during their menstrual cycle. Effective birth control must be used while using Duobrii to prevent pregnancy.

• Hormonal Effects: The halobetasol component in Duobrii is a corticosteroid that can alter stress hormone levels, potentially leading to weight gain and elevated blood sugar. This risk increases if the medication is applied over large skin areas, used for prolonged periods, or if the treated area is covered with tight bandages. Extra caution is needed for young children, individuals with liver problems, or those applying multiple topical steroids.

• Skin Reactions: Duobrii can cause skin irritation, such as dryness, redness, or a burning sensation. It may also lead to thinning of the skin, stretch marks, or a rash. Avoid using this medication on areas with eczema to prevent severe irritation. If you experience persistent skin reactions, inform your prescriber.

• Sun Sensitivity: This medication can increase your skin's sensitivity to sunlight, heightening the risk of sunburn. The risk is greater if you are taking other sun-sensitizing medications like thiazides, tetracyclines, or fluoroquinolones. Minimize sun exposure, use sunscreen, and wear protective clothing outdoors. If you get sunburned, consult your prescriber about pausing the medication until recovery.

• Vision Concerns: Although rare, topical use of steroids such as halobetasol may increase the risk of cataracts or glaucoma. Inform your prescriber if you have a history of these eye conditions or experience vision changes during treatment.

• Contraindications: Duobrii should not be used if you are currently pregnant due to potential serious health risks. Always discuss with your healthcare provider if any of these conditions apply to you before starting the medication.

When using this medication, some individuals may experience mild side effects such as skin irritation, redness, itching, burning, stinging, dryness, or peeling at the application site. These effects are generally not serious and often subside on their own, but if they persist or worsen, it is advisable to consult a healthcare provider. Some people may also notice skin rash or discomfort where the medication is applied.

There are other side effects that could occur, including inflamed hair follicles (folliculitis), skin thinning, and unexpected hair growth at the application site. Although these are not common, they should be discussed with a healthcare professional if they arise. Additionally, issues like repeated skin picking and peeling could also occur in some users.

Severe side effects are rare but require immediate medical attention. These include allergic reactions characterized by skin rash, hives, swelling of the face, lips, tongue, or throat, and difficulty breathing. Serious symptoms such as fragile or thinning skin that bruises easily, signs of skin infection (redness, swelling, warmth, pain), and sudden changes in vision like seeing halos around lights should prompt urgent medical consultation.

Furthermore, rare but significant side effects, particularly in children or those using the medication extensively or for prolonged periods, include symptoms of excessive corticosteroid absorption such as unusual tiredness, weight loss, headaches, swelling of the ankles or feet, increased thirst or urination, and vision problems. If any of these symptoms occur, it is crucial to seek medical advice promptly.