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The following information outlines critical safety and warning details for the use of this medication. It is important to read these carefully and discuss any concerns with your healthcare provider.

• Overdose Risks: Calcitriol (Rocaltrol) is a potent form of vitamin D, and excessive intake may lead to dangerously high calcium levels in the blood, affecting your kidneys and blood vessels. Maintain a consistent intake of calcium through diet or supplements. Be alert to symptoms of elevated calcium, such as a metallic taste, dry mouth, muscle or bone pain, or headache. If you experience any of these, contact your provider immediately for a possible lab check and treatment to reduce calcium levels, if necessary.

• Drug Interactions: Calcitriol (Rocaltrol) may interact with several medications, including ketoconazole, cholestyramine (Prevalite), corticosteroids, phosphate binders, magnesium-containing supplements or antacids, and diuretics like hydrochlorothiazide. These interactions can alter the levels of calcitriol, vitamin D, calcium, or other electrolytes in your body. Ensure all your healthcare providers are aware of all medications and supplements you are taking to appropriately adjust doses and avoid adverse interactions.

• Contraindications: This medication should not be used if you have high levels of calcium or vitamin D, as it can pose serious health risks. Prior to starting this medication, discuss any pre-existing conditions with your healthcare provider to determine if it's safe for you.

Common side effects:

• headache
• weakness
• fatigue
• nausea
• vomiting
• constipation
• loss of appetite
• muscle or bone pain
• dry mouth
• metallic taste

Less common but important to monitor:

• light sensitivity
• changes in urine
• chest pain
• racing heart
• itching
• rash
• hives
• swelling around the lips

Serious side effects:

• severe allergic reactions with facial swelling
• changes in heart rhythm such as fast or irregular heartbeat
• dizziness
• trouble breathing
• chest pain
• high calcium levels leading to increased thirst
• frequent urination
• confusion
• unusual fatigue
• high phosphorus levels causing muscle cramps
• numbness around the mouth

Interactions with high risk of serious adverse effects and should be avoided:

• Burosumab
• Cardiac glycosides (such as Digoxin, digitalis)

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Magnesium-containing medications (such as antacids, Milk Of Magnesia)
• Phosphate binders
• Vitamins/nutritional supplements (especially Calcium and Vitamin D)
• Drugs that can speed up the removal of calcitriol (such as Ketoconazole, Phenobarbital, Phenytoin)