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This document outlines the critical safety information and warnings associated with the use of alprostadil injection. It is crucial to read these details carefully and discuss any concerns with your healthcare provider.

• Prolonged Erection (Priapism): Seek immediate medical attention if you experience an erection lasting more than 4 hours, as it may result in permanent damage. Individuals with conditions like sickle cell anemia, multiple myeloma, or leukemia should avoid this medication. Your healthcare provider will prescribe the lowest effective dose and monitor your condition every 3 months. Do not alter your dosage without consulting your provider.

• Penile Scarring: There is a rare risk of scarring and penile curvature with prolonged use. Regular physical examinations will be conducted to detect scarring, and treatment will be discontinued if necessary.

• Low Blood Pressure: Alprostadil may cause a drop in blood pressure, resulting in dizziness or fainting. If you experience these symptoms, sit down immediately. Use the minimal effective dose, especially if you are taking other blood pressure-lowering drugs.

• Injection Site Bleeding: Minor bleeding can occur at the injection site, especially if you are on blood thinners or have bleeding disorders. Apply pressure with sterile gauze or an alcohol swab for 5 minutes post-injection. Discuss the risks with your provider if you are on blood thinners.

• Heart Concerns During Sexual Activity: Sexual activity can strain the heart, posing risks for individuals with heart conditions. Avoid alprostadil if advised against sexual activity due to heart problems. Contact your healthcare provider if you experience chest pain, dizziness, or nausea.

• Needle Breakage: Alprostadil requires a very thin needle, which can break during injection. Proper instruction on self-injection is essential. Consult your healthcare provider or pharmacist if you have questions.

• Not for Children: Caverject and Caverject Impulse contain benzyl alcohol, which can cause severe side effects in children. Only Prostin VR is used in hospitals for newborns with specific heart conditions. Do not use Caverject, Caverject Impulse, or edex in children.

• Sexually Transmitted Infections (STIs): Alprostadil does not protect against STIs, including HIV. To reduce risk, use condoms, get tested regularly, and consider birth control for female partners of childbearing age.

Contraindications: Avoid alprostadil if you have conditions leading to prolonged erections (e.g., sickle cell anemia, leukemia, multiple myeloma), abnormal penile structure or Peyronie's disease, or penile implants. Always consult your healthcare provider before starting this medication if any of these conditions apply to you.

When using this medication, some individuals may experience mild or common side effects. These can include pain, irritation, slight bleeding, or bruising at the injection site. Penile pain is relatively common, affecting up to 37% of users. While these effects are generally mild, it's important to inform your healthcare provider if they persist or worsen, to ensure appropriate management.

There are also other side effects that may occur, such as penile curvature, scar tissue formation in the penis, and blood pooling or hematoma near the injection site. Although these are not experienced by everyone, monitoring these symptoms is crucial, and you should seek medical advice if they become concerning.

In rare cases, severe side effects may develop, which require immediate medical attention. These include prolonged erections lasting more than four hours, which can lead to permanent complications if not treated promptly. Additionally, severe allergic reactions, characterized by rash, itching, swelling of the face, tongue, or throat, severe dizziness, or difficulty breathing, are serious and necessitate urgent care. Heart-related symptoms like chest pain, dizziness, or nausea also require immediate medical intervention. Always consult your healthcare provider with any concerns regarding side effects.