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This medication requires careful consideration due to several important safety warnings and precautions. Please review the following information and consult your healthcare provider if you have any concerns or questions.

• Pregnancy Risks: This medication can cause serious, potentially fatal harm to an unborn baby. It is crucial to avoid pregnancy while using this drug. Discuss reliable birth control methods with your doctor. If you are planning to become pregnant, become pregnant, or suspect you might be pregnant, contact your healthcare provider immediately.

• Angioedema: This medication, which contains an ACE inhibitor, may cause a rare but serious condition known as angioedema, leading to swelling in various body parts, such as the face, throat, and tongue. This swelling can be life-threatening if it obstructs breathing. The risk is higher for Black individuals, older adults, or females. Seek immediate medical attention if you experience any swelling, stomach pain, or difficulty breathing, and discontinue use of the medication.

• Low Blood Pressure: The medication can lead to a significant drop in blood pressure, causing dizziness, tiredness, or lightheadedness, especially initially or when the dosage is increased. Stay well-hydrated and contact your provider if you experience these symptoms. If you fall and injure yourself, seek medical assistance promptly.

• Kidney Concerns: While generally beneficial for the kidneys, this medication can exacerbate certain kidney issues, particularly in individuals with renal artery stenosis or severe heart failure. Regular kidney function tests may be necessary. Inform your provider if you notice a reduction in urination frequency.

• High Potassium Levels: This medication can elevate potassium levels in the body, posing a risk, especially for those with diabetes, kidney problems, or those on other potassium-raising drugs. Monitor for symptoms like nausea, muscle weakness, or irregular heartbeat, and inform your provider immediately.

• Liver Health: There have been rare instances of liver problems, including liver failure, in individuals on ACE inhibitors like this medication. Regular liver function tests may be recommended. Report any signs of liver issues, such as fatigue, abdominal pain, or jaundice, to your provider.

Contraindications: Avoid using this medication if you have a history of angioedema, are on aliskiren (Tekturna) with high blood sugar, or are using neprilysin inhibitors like Entresto (sacubitril/valsartan) within 36 hours. Consult your healthcare provider for further guidance.

When taking this medication, you might experience some common side effects as your body adjusts. These include feeling tired, dizziness, lightheadedness, or weakness, especially when standing up from a sitting position. A dry cough and occasional rash may also occur. These effects are generally mild, but if they persist or worsen, consult your healthcare provider for guidance.

There are some rare but serious side effects that require immediate medical attention. These include signs of a severe allergic reaction, such as trouble breathing, swelling of the face, lips, tongue, or throat, and severe dizziness. Additionally, watch for symptoms of angioedema, which include swelling in the face, lips, tongue, throat, hands, or feet, along with possible breathing difficulties.

Kidney problems, either new or worsening, can also be a serious side effect. Symptoms to be aware of include a noticeable change in urination, swelling in the feet, ankles, or hands, and unexplained weight gain. This medication can sometimes lead to high blood potassium levels, indicated by muscle weakness, chest pain, nausea, or a pounding heart.

Lastly, be cautious of severely low blood pressure, which may present as significant dizziness, lightheadedness, or feeling faint. If you experience any of these severe side effects, seek medical help immediately. While many people do not experience serious side effects, it's important to be vigilant and communicate any concerns to your healthcare provider.

Enalapril (Vasotec) can interact with a variety of medications and supplements, which is why it's important to inform your healthcare provider about all the medicines you're taking, including over-the-counter drugs, vitamins, and herbal supplements.

Some drugs that should not be combined with enalapril include aliskiren and sacubitril, as these interactions could potentially be harmful. Additionally, medications like everolimus, sirolimus, lithium, and certain potassium-increasing drugs such as ARBs (losartan, valsartan) and drospirenone-containing birth control pills may require special consideration. Your doctor might need to adjust your medication dosage or frequency to manage these interactions safely.

Furthermore, enalapril may interact with drugs that can elevate blood pressure or exacerbate heart failure. This includes products like NSAIDs (e.g., ibuprofen, naproxen) and certain cough-and-cold medications. Be sure to consult your pharmacist about the safe use of these products.

Lastly, it is crucial to inform all of your healthcare providers if you are receiving allergy injections for bee or wasp stings while taking enalapril, as this combination could lead to a serious reaction.