Sofosbuvir-velpatasvir

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sofosbuvir-velpatasvir

Epclusa is a medication combining sofosbuvir and velpatasvir, used to treat chronic hepatitis C in both adults and children. This condition is a long-term viral infection affecting the liver, which can lead to serious issues like liver scarring (cirrhosis) or liver cancer. The medication works by containing two antiviral agents that prevent the hepatitis C virus from replicating in the body. By reducing the virus levels, Epclusa aids your immune system in fighting the infection and supports liver recovery. While effective in treating the infection, it is not confirmed whether Epclusa prevents the transmission of the virus to others. Therefore, it is advised to avoid sharing needles and to practice safer sex, including using latex condoms, to minimize the risk of spreading the virus. Always consult healthcare professionals such as your doctor, nurse, or pharmacist before starting any new medication.
Our Epclusa coupons are free to use. You can print the coupon, email it to yourself, or receive the Epclusa coupon via text message. To get your free discount, show the pharmacist your Epclusa savings card which has the discounted coupon price. Use our filters below to edit the prescription box to match your needs. The Epclusa prices will update based on your prescription needs. Above our Epclusa coupons, you can change the location to see pharmacy prices in other areas. Our prescription discount card will update online with the specific pharmacy costs associated with your edits. Be sure to text, email, or print the Epclusa savings card code that you need after editing the prescription box and location field. Show the discount card to your pharmacist before paying.

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400-100MG, Sofosbuvir-velpatasvir (30 Tablets)

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Walgreens

$8889.14

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Walgreens

$8889.14

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Epclusa dosage forms

The average cost for 30 Tablets of Epclusa (sofosbuvir-velpatasvir) at 400-100MG is $8316.32 with a free coupon. This is 27.40% off the average retail price of $30347.62
DosageQuantityPrice fromPer unit
400-100MG30 Tablets$8316.32$277.21

Epclusa Warnings

When taking Epclusa (sofosbuvir/velpatasvir) for hepatitis C, it is crucial to be aware of several important safety considerations and potential risks. Below is a summary of the key warnings and precautions associated with this medication:

  • Hepatitis B Reactivation: Patients who have had hepatitis B in the past or are co-infected with hepatitis B and C may experience a reactivation of hepatitis B when starting treatment with Epclusa. This can result in serious liver problems or even be life-threatening if not addressed promptly. It is essential to be tested for hepatitis B before beginning treatment and to inform your healthcare provider of any history of hepatitis B.

  • Slow Heart Rate Risks: Combining Epclusa with amiodarone has been associated with slow heart rate and potentially fatal heart complications. This risk is heightened if you also take beta blockers or have advanced liver or heart disease. Inform your healthcare provider if you are using amiodarone or have recently used it, as alternative treatments may be necessary or close heart monitoring may be required. Seek immediate medical attention if you experience symptoms like faintness, dizziness, weakness, or breathing difficulties.

  • Ribavirin Considerations: In some cases, individuals with certain liver conditions may need to use ribavirin alongside Epclusa. Ribavirin can lead to numerous side effects, so thorough discussion with your healthcare provider and pharmacist is advised before starting this combination therapy.

  • Drug and Supplement Interactions: Epclusa interacts with several medications and some herbal supplements. Drugs such as rifampin, carbamazepine, and supplements like St. John's wort can reduce the effectiveness of Epclusa. It is crucial to inform your healthcare provider and pharmacist about all the medications, vitamins, herbal products, and over-the-counter drugs you are taking.

In case of any adverse reactions or concerns regarding the use of Epclusa, consult your healthcare provider for further guidance and management.

Epclusa Side Effects

When taking this medication, you may experience some common side effects such as tiredness, headache, nausea, diarrhea, or difficulty sleeping. These effects are usually mild and often do not require medical attention. However, if they persist or worsen, it is advisable to consult your healthcare provider for guidance.

In some cases, individuals may also report experiencing weakness or a skin rash. These side effects are generally manageable, but if you find them bothersome, do not hesitate to reach out to your healthcare provider for advice.

On rare occasions, serious allergic reactions can occur. Be vigilant for signs such as a rash, itching, hives, or swelling, particularly around the face, lips, tongue, or throat, as well as severe dizziness or trouble breathing. These symptoms necessitate immediate medical attention to ensure your safety.

It is important to remember that this list does not cover all possible side effects. If you notice any other symptoms or have concerns about your health while taking this medication, contacting your healthcare provider is recommended.

Epclusa Interactions

Certain medications can interact with sofosbuvir/velpatasvir, potentially altering its effectiveness. For instance, amiodarone may slow the removal of other drugs from your system, impacting their performance, including medications like topotecan. Additionally, drugs such as apalutamide, efavirenz, rifamycins (e.g., rifampin, rifabutin), St. John's wort, tipranavir/ritonavir, and seizure medications like phenobarbital, carbamazepine, phenytoin, and primidone can influence how sofosbuvir/velpatasvir is processed in your body. It is crucial not to use sofosbuvir/velpatasvir with any other products containing sofosbuvir.
Epclusa FAQs
What does Epclusa do to your body?

Epclusa is an antiviral medication used to treat chronic hepatitis C infection. It works by reducing the amount of hepatitis C virus in the body, which helps the immune system fight the infection and can lead to the virus being cleared from the body. This can prevent liver damage, cirrhosis, and liver cancer.

The cost of a 12-week course of Epclusa can vary significantly depending on factors such as location, insurance coverage, and pharmacy pricing. Without insurance, the list price for Epclusa is typically around $74,760 for a 12-week supply. However, patients are encouraged to check with their insurance provider or pharmacy for specific pricing and potential financial assistance programs that may be available to help reduce the cost.

The average cost of hepatitis C treatment can vary significantly depending on the specific medication regimen, duration of treatment, and geographic location. As of the latest data, the cost for a full course of direct-acting antiviral (DAA) therapy can range from $26,000 to $94,500. However, prices may be lower with insurance coverage, patient assistance programs, or generic options. It is advisable for individuals to consult with their healthcare provider or insurance company for more precise cost information based on their specific circumstances.

It is generally advised to avoid alcohol while taking Epclusa. Alcohol can increase the risk of liver damage, which is a concern for individuals being treated for hepatitis C. It is important to follow the healthcare provider's recommendations and discuss any alcohol consumption with them to ensure safe and effective treatment.

Epclusa has a high success rate, with clinical trials showing a sustained virologic response (SVR) rate of approximately 95% to 99% in patients with chronic hepatitis C, across all genotypes. This means that the majority of patients achieve a cure, defined as having no detectable hepatitis C virus in the blood 12 weeks after completing treatment.