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It is crucial to be informed about the safety and warning details associated with the use of Vemlidy (tenofovir alafenamide). Below are key points to consider, which include potential risks, necessary precautions, and special instructions for certain situations:

• Worsening of Hepatitis B: Do not discontinue the use of Vemlidy (tenofovir alafenamide) without consulting your healthcare provider. Abrupt cessation can lead to a resurgence and worsening of your hepatitis B infection, complicating treatment. If a change in medication is necessary, your healthcare provider will conduct regular liver function tests to monitor your condition.

• Coinfection with Hepatitis B and HIV: Vemlidy (tenofovir alafenamide) is approved for hepatitis B treatment only and should not be used alone for HIV. If you are HIV positive, inform your healthcare provider immediately to adjust your treatment appropriately. Using Vemlidy alone for HIV could lead to drug resistance, making the virus harder to treat.

• Kidney Health: There is a potential for kidney problems when using Vemlidy (tenofovir alafenamide), which might occur soon after starting the medication or develop gradually. To prevent complications, avoid concurrent use of medications that may harm the kidneys, such as high doses of NSAIDs. Regular kidney function tests may be recommended by your healthcare provider.

• Liver Health: Though rare, Vemlidy (tenofovir alafenamide) may cause a severe liver condition known as lactic acidosis with hepatic steatosis. Symptoms to watch for include loss of appetite, abdominal pain, muscle pain, rapid or shallow breathing, extreme fatigue, and sudden weakness. Should these occur, discontinue use immediately and seek medical attention.

• Contraindications: Vemlidy (tenofovir alafenamide) should not be used alone to treat HIV, as this poses significant health risks. Always consult your healthcare provider if you have questions or if any contraindications apply to you.

In case of an overdose, seek emergency medical assistance right away. Always follow your healthcare provider's guidance and ensure regular check-ups to monitor your health while using this medication.

When taking this medication, you might experience some common side effects, which are generally mild. These include headache, stomach pain, cough, back pain, tiredness, and nausea. These symptoms are usually not a cause for concern, but if they persist or worsen, it's advisable to consult your healthcare provider.

There are other side effects that have been reported by some users, such as joint pain, diarrhea, upset stomach, vomiting, rash, and passing gas. While these are not uncommon, it's important to monitor how you feel and reach out to your healthcare provider if any of these symptoms become bothersome.

On a more serious note, there are rare but severe side effects that require immediate medical attention. These include the build-up of lactic acid in the blood, characterized by unusual tiredness, muscle pain, stomach discomfort, and breathing difficulties. Inflammation of the pancreas is another serious side effect, indicated by fever, nausea, persistent severe stomach pain, and a fast heartbeat. Additionally, serious kidney problems may manifest as tiredness, confusion, nausea, reduced urination, and swelling in the legs. Serious liver issues may present with symptoms such as confusion, sleepiness, lack of appetite, dark urine, and yellowing of the skin or eyes. If you experience any of these severe symptoms, seek urgent medical care promptly. Always keep an eye out for any unusual reactions and consult your healthcare provider if needed.