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When taking cetirizine, it is important to be mindful of potential interactions and precautions to ensure safe use. Here are key points to consider:

• Inform your doctor or pharmacist if you are using any other substances that may cause drowsiness. This includes opioid pain or cough medications (like codeine or hydrocodone), alcohol, marijuana, sleep or anxiety drugs (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or other antihistamines (such as chlorpheniramine, diphenhydramine).
• Carefully review the labels on all medications you are taking, including those for allergies or cough-and-cold, as they may contain ingredients that induce drowsiness. Consult your pharmacist for guidance on safe usage.
• Avoid using cetirizine with other antihistamines that are applied topically, such as diphenhydramine cream, ointment, or spray, to prevent increased side effects.
• Do not combine cetirizine with medications closely related to it, such as hydroxyzine and levocetirizine.
• Be aware that cetirizine may affect certain laboratory tests, such as allergy skin tests, potentially leading to inaccurate results. Ensure that laboratory personnel and all healthcare providers are informed of your cetirizine use.

By following these guidelines, you can help minimize risks and ensure the effective and safe use of cetirizine.