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Lorazepam is a medication that requires careful use due to several potential risks and side effects. It is important to follow the guidance of your healthcare provider closely to minimize risks. Below are key safety considerations and warnings associated with lorazepam:

• Risk of Abuse and Addiction: Lorazepam can lead to misuse and addiction, even at prescribed doses. Misuse can increase the risk of overdose, which can be life-threatening. To reduce these risks, use the smallest effective dose for the shortest duration possible.

• Sedation and Breathing Difficulties: Combining lorazepam with alcohol or opioid medications (e.g., codeine, hydrocodone) can cause severe drowsiness and breathing problems, potentially leading to life-threatening situations. Avoid using lorazepam with these substances.

• Withdrawal Concerns: Suddenly stopping lorazepam can cause serious withdrawal symptoms, which may include headaches, trouble sleeping, restlessness, hallucinations, confusion, depression, nausea, and seizures. These symptoms can last for weeks or months. Your doctor may gradually reduce your dosage to prevent withdrawal.

• Impact on Mental Health: Lorazepam may worsen depression or cause suicidal thoughts or changes in mood and behavior. Seek immediate medical attention if you notice these symptoms, and discuss alternative treatments with your healthcare provider if needed.

• Effects on Alertness and Concentration: Lorazepam can impair your ability to concentrate and stay alert. Avoid activities requiring full attention, such as driving, until you know how the medication affects you. Alcohol and other drowsiness-inducing medications can exacerbate these effects.

• Age-Related Risks: Individuals over 65 are more susceptible to side effects like breathing difficulties and agitation. Healthcare providers typically prescribe lower doses for older adults to mitigate these risks. Notify your healthcare provider if you experience trouble breathing or agitation.

• Use During Pregnancy: Taking lorazepam during pregnancy can harm the unborn baby, leading to issues like breathing problems and drowsiness in newborns. If you are pregnant or planning to become pregnant, consult your healthcare provider to explore safer treatment options.

• Allergic Reactions: Loreev XR capsules contain FD&C Yellow No. 5 (tartrazine), which can cause allergic reactions in some people. Avoid this medication if you are allergic to this ingredient.

• Contraindications: Do not use lorazepam if you have acute narrow-angle glaucoma, as it may pose serious health risks.

In case of an overdose, seek emergency medical help immediately. Always communicate openly with your healthcare provider about any concerns or unusual symptoms you experience while taking lorazepam.

Common side effects:

• drowsiness
• dizziness
• weakness
• unsteadiness
• headache
• nausea
• blurred vision
• constipation
• heartburn
• changes in appetite
• variations in sexual interest or ability

Less common but important to monitor:

• confusion
• mood changes
• trouble speaking
• opposite effects such as agitation, irritability, or restlessness

Serious side effects:

• depression
• hallucinations
• suicidal thoughts
• vision changes
• unusual weakness
• trouble walking
• signs of infection like persistent sore throat or fever
• yellowing of the eyes or skin
• seizures
• slow and shallow breathing
• serious allergic reaction marked by rash, itching, swelling, severe dizziness, or trouble breathing

Interactions with high risk of serious adverse effects and should be avoided:

• Flumazenil

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Clozapine
• Sodium oxybate (GHB)
• Opioid pain or cough relievers (such as codeine, hydrocodone)
• Other drugs for sleep or anxiety (such as Alprazolam, Diazepam, Zolpidem)
• Muscle relaxants (such as Carisoprodol, Cyclobenzaprine)
• Antihistamines (such as Cetirizine, diphenhydramine)
• Alfentanil
• Amobarbital
• Anileridine
• Benzhydrocodone
• Bromazepam
• Bromopride
• Buprenorphine
• Butabarbital
• Butalbital
• Butorphanol
• Cannabidiol
• Carbinoxamine
• Chloral Hydrate
• Chlorzoxazone
• Clobazam
• Dantrolene
• Dezocine
• Diacetylmorphine
• Difenoxin
• Dihydrocodeine
• Diphenoxylate
• Doxylamine
• Esketamine
• Ethchlorvynol
• Ethylmorphine
• Fentanyl
• Flibanserin
• Fospropofol
• Gabapentin
• GabapentinEnacarbil
• Hydromorphone
• Ketamine
• Ketobemidone
• Lemborexant
• Levocetirizine
• Levorphanol
• Lofexidine
• Loxapine
• Meclizine
• Meperidine
• Mephenesin
• Mephobarbital
• Meprobamate
• Meptazinol
• Metaxalone
• Methadone
• Methocarbamol
• Methohexital
• Metoclopramide
• Midazolam
• Mirtazapine
• Morphine
• MorphineSulfate Liposome
• Nalbuphine
• Nicomorphine
• Opium
• OpiumAlkaloids
• Orlistat
• Oxycodone
• Oxymorphone
• Papaveretum
• Paregoric
• Pentazocine
• Pentobarbital
• Periciazine
• Phenobarbital
• Piritramide
• Potassium Oxybate
• Pregabalin
• Primidone
• Propofol
• Remifentanil
• Remimazolam
• Scopolamine
• Secobarbital
• Sodium Oxybate
• Sufentanil
• Tapentadol
• Thiopental
• Tilidine
• Tramadol
• Trazodone

Interactions with low risk that usually do not require a change in therapy:

• Desogestrel
• Dienogest
• Drospirenone
• Estradiol
• EthinylEstradiol
• Ethynodiol
• Gestodene
• Levonorgestrel
• Mestranol
• Nomegestrol
• Norethindrone
• Norgestimate
• Norgestrel
• Posaconazole
• Probenecid
• Pyrimethamine
• Rifapentine
• St John's Wort
• Theophylline
• Valproic Acid