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This safety information outlines crucial warnings and potential risks associated with the use of cyclobenzaprine. Please read thoroughly and discuss any concerns with your healthcare provider.

• Serotonin Syndrome: Cyclobenzaprine can contribute to serotonin syndrome, a rare but potentially fatal condition caused by excessive serotonin in the brain. This risk increases when combined with other medications that elevate serotonin levels, such as some antidepressants, migraine, and pain medications. Be sure to inform your pharmacist of all prescribed and over-the-counter medications you are taking. Symptoms to watch for include rapid heart rate, excessive sweating, muscle stiffness, fever, and mental confusion. Seek immediate medical attention if these occur.

• Impact on Alertness: Cyclobenzaprine may induce drowsiness and impair concentration, particularly in individuals over 65 or those taking other sedative medications. Alcohol can exacerbate these effects. It is advised to avoid driving, operating machinery, or engaging in tasks that require alertness until you understand how the medication affects you.

• Dryness and Urination Issues: This medication can cause dryness of the mouth and eyes, as well as difficulty urinating, due to its mechanism of action. Individuals with glaucoma, high eye pressure, or urinary issues should exercise caution, as cyclobenzaprine may worsen these conditions. Those using other medications with similar side effects should notify their healthcare provider.

• Liver Function Considerations: Cyclobenzaprine is metabolized by the liver, making it crucial for individuals with liver issues to use caution. Those with severe liver dysfunction are advised against using this medication due to the risk of prolonged concentration in the body, increasing side effects like dizziness and drowsiness. Disclose any liver health history to your provider before beginning treatment.

Contraindications: Cyclobenzaprine should not be used under the following conditions due to significant health risks:

• Recent use of a monoamine oxidase inhibitor (MAOI) within the past 14 days.
• History of a recent heart attack.
• Existing heart conditions such as abnormal rhythm, heart block, or heart failure.
• Hyperthyroidism (elevated thyroid levels).

Consult your healthcare professional if any of these contraindications apply to you.

Common side effects:

• Drowsiness
• Dry mouth
• Dizziness
• Tiredness
• Headache

Less common but important to monitor:

• Indigestion
• Nausea
• Constipation

Serious side effects:

• Diarrhea
• Blurry vision
• Irritability
• Confusion
• Nervousness
• Weakness
• Rash
• Itching/swelling
• Severe dizziness
• Trouble breathing

Interactions with high risk of serious adverse effects and should be avoided:

• MAO inhibitors (isocarboxazid, Linezolid, methylene blue, moclobemide, phenelzine, procarbazine, Rasagiline, safinamide, Selegiline, Tranylcypromine)

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• tricyclic antidepressants (Amitriptyline, imipramine)
• drugs that increase serotonin (SSRIs like Fluoxetine, paroxetine, SNRIs like Duloxetine, Venlafaxine, Tramadol, St. John's wort, MDMA)

Interactions with low risk that usually do not require a change in therapy:

• products that cause drowsiness (opioid pain relievers like codeine, hydrocodone, alcohol, cannabis, sleep or anxiety medications like Alprazolam, Lorazepam, Zolpidem, muscle relaxants like Carisoprodol, Methocarbamol, antihistamines like Cetirizine, diphenhydramine)