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This safety information outlines crucial warnings and precautions for those considering the use of cetirizine (Zyrtec). Please read carefully and consult your healthcare provider for any concerns.

• Drowsiness Risk: Cetirizine may cause drowsiness, potentially impairing your focus, cognition, and reaction times. This effect is heightened if you are over 65, consume alcohol, or take other sedatives like opioids or anxiety medications. Avoid driving or operating machinery until you understand how cetirizine affects you.

• Overdose Warning: Cetirizine is present in many over-the-counter products, and excessive consumption can lead to overdose, resulting in severe side effects such as seizures, hallucinations, or even death. Be cautious not to take multiple products containing antihistamines simultaneously.

• Contraindications: Do not use cetirizine if you are allergic to hydroxyzine (Vistaril), as this may lead to significant health complications. If this applies to you, seek advice from your healthcare provider before using cetirizine.

Common side effects:

• Sleepiness
• Tiredness
• Dry mouth
• Headaches
• Sore throat
• Stomach pain
• Cough

Serious side effects:

• Persistent sore throat
• Dizziness

When taking cetirizine, it's important to be aware of potential interactions with other substances that can enhance side effects or reduce the medication's effectiveness. Here are some key interactions to consider:

Alcohol: Consuming alcohol while on cetirizine can increase drowsiness and decrease alertness. It's advisable to avoid alcohol during treatment to prevent these effects.

Other Antihistamines: Combining cetirizine with other antihistamines, such as diphenhydramine, can lead to excessive sedation and increase the risk of side effects. It's best to avoid using multiple antihistamines simultaneously unless directed by a healthcare professional.

Central Nervous System (CNS) Depressants: Cetirizine can enhance the sedative effects of medications that depress the central nervous system. This includes:

• Benzodiazepines: Medications like Alprazolam (Xanax) and Lorazepam (Ativan) can cause increased drowsiness when taken with cetirizine.

• Opioids: Pain relievers such as Oxycodone (OxyContin) and hydrocodone (Vicodin) may lead to heightened sedation when combined with cetirizine.

• Sleep Aids: Drugs like Zolpidem (Ambien) and Eszopiclone (Lunesta) can result in increased drowsiness if taken alongside cetirizine.

Muscle Relaxants: Medications such as Cyclobenzaprine and Baclofen can amplify the sedative effects of cetirizine, leading to increased drowsiness.

Theophylline: Used for asthma and other lung conditions, theophylline can interfere with the metabolism of cetirizine, potentially increasing its side effects.

Monoamine Oxidase Inhibitors (MAOIs): Drugs like isocarboxazid and Tranylcypromine, used to treat depression, can prolong and intensify the anticholinergic effects of antihistamines like cetirizine.

Herbal Supplements: Certain herbs, such as valerian, which are used to aid sleep, can increase drowsiness when taken with cetirizine.

Health Conditions: Individuals with liver or kidney problems may have difficulty clearing cetirizine from their system, leading to increased side effects. It's important to inform your healthcare provider of any existing health conditions before starting cetirizine.

Always consult with your doctor or pharmacist before combining cetirizine with other medications or supplements to ensure safety and effectiveness.