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The following safety information outlines important risks and precautions associated with the use of topical hydrocortisone. It is crucial to read these warnings carefully and discuss any concerns with your healthcare provider.

• Hormonal Issues and Withdrawal: Prolonged and extensive use of topical hydrocortisone may lead to adrenal suppression, a condition where the body reduces its own steroid hormone production due to the external steroid source. Sudden discontinuation can result in withdrawal symptoms such as skin swelling, rash, and a burning sensation. To minimize this risk, your healthcare provider will prescribe the lowest effective dose for the shortest duration. If extended use is necessary, you may need lab tests to evaluate adrenal function. Do not stop using the medication abruptly without consulting your provider. Risks are heightened with prolonged use, excessive application, covering the treated area, and in young children.

• Elevated Blood Sugar Levels: Continuous application of topical hydrocortisone over large areas can increase blood sugar levels, potentially leading to diabetes. If you already have diabetes, your healthcare provider may recommend regular monitoring of blood sugar levels to ensure safety. Report any increased thirst or urination to your provider. Risks increase with prolonged use and excessive dosage.

• Increased Infection Risk: Long-term use of topical hydrocortisone can make you susceptible to skin or oral infections, including fungal and bacterial types. Avoid using this medication if you have a skin infection, as it may exacerbate the condition. Contact your healthcare provider if you notice redness, swelling, pain, pus, or if symptoms do not improve after seven days, as these may indicate a new infection. The risk is higher with use beyond seven days.

• Skin Reactions: Extended use of topical hydrocortisone beyond the recommended duration can cause various skin issues such as thinning, stretch marks, spider veins, burning, itching, irritation, dryness, inflamed hair follicles, changes in skin color, or rash. To prevent these reactions, your provider will prescribe the minimal effective dose for the shortest time necessary. Immediately inform your provider if you experience new or worsening skin problems. Risks are elevated with excessive and improper use.

Please ensure that you follow your healthcare provider's guidance when using this medication to mitigate these risks.

Common side effects:

• Stinging
• Burning
• Itching
• Irritation
• Dryness
• Redness at the application site

Less common but important to monitor:

• Acne-like bumps
• Changes in skin color
• Thinning skin
• Stretch marks
• Increased hair growth
• Inflamed hair follicles
• Rashes

Serious side effects:

• Severe allergic reactions
• Swelling of the face, tongue, or throat
• Dizziness
• Difficulty breathing
• Unusual fatigue
• Weight loss
• Headaches
• Swelling of the ankles or feet
• Increased thirst or urination
• Vision problems

Hydrocortisone valerate is a topical corticosteroid used to treat various skin conditions. While it is applied externally, it's important to be aware of potential interactions with other medications, supplements, and health conditions.

Drug Interactions:

• Diuretics: Using hydrocortisone valerate with diuretics may increase the risk of low potassium levels (hypokalemia).

• Anticoagulants (e.g., Warfarin): Hydrocortisone can affect blood clotting, potentially altering the effectiveness of anticoagulants.

• Antidiabetic Medications: Corticosteroids may raise blood sugar levels, which can interfere with the effectiveness of diabetes medications.

• Vaccines: Hydrocortisone may reduce the effectiveness of certain vaccines.

Nutrient Interactions:

• Calcium and Vitamin D: Corticosteroids can decrease calcium absorption and affect vitamin D metabolism, increasing the risk of bone loss. Supplementing with calcium and vitamin D may help mitigate this risk.

• Chromium: Corticosteroids may increase chromium loss, potentially affecting blood sugar control.

• Vitamin B6: There is some evidence that corticosteroids may increase the loss of vitamin B6.

Health Conditions:

• Diabetes and High Blood Sugar: Hydrocortisone can raise blood sugar levels, which may worsen diabetes or lead to hyperglycemia.

• Infections: Applying hydrocortisone to infected areas may exacerbate the infection.

• Skin Conditions: Using hydrocortisone on large sores, broken skin, or severe injuries can increase the risk of side effects.

General Advice:

Always inform your healthcare provider about all medications, supplements, and health conditions before using hydrocortisone valerate. They can provide guidance on potential interactions and monitor for any adverse effects.