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This medication, Invega (paliperidone), comes with important safety information that you should be aware of before starting treatment. It's crucial to discuss any concerns or conditions with your healthcare provider to ensure safe use. Please read the following warnings and precautions carefully:

• Increased Risk for Older Adults with Dementia: Invega is not approved for treating dementia-related behavior problems and may increase the risk of serious, possibly fatal side effects such as stroke, heart failure, irregular heartbeat, or pneumonia in older adults with dementia-related psychosis. Discuss all treatment options with your healthcare provider before use.

• Neuroleptic Malignant Syndrome (NMS): This medication may cause NMS, a rare but serious condition that can be life-threatening. Symptoms include high fever, stiff muscles, confusion, rapid or irregular heartbeat, and excessive sweating. Seek immediate medical attention if these occur.

• Metabolic Changes: Invega can lead to high blood sugar, cholesterol levels, and weight gain. Monitor for symptoms of high blood sugar, such as increased hunger, thirst, frequent urination, abdominal pain, weakness, or fruity-smelling breath. Inform your healthcare provider if you have a history of diabetes or high cholesterol.

• Tardive Dyskinesia: This medication may cause involuntary and potentially permanent muscle movements, known as tardive dyskinesia. This risk is higher in older adults, females over 65, those on high doses, or long-term users. Report any uncontrollable movements immediately to your healthcare provider.

• Risk of Falls: Invega can cause dizziness, sleepiness, and blood pressure drops, leading to fainting and falls. Be cautious when standing or sitting up quickly, especially at the start of treatment or after a dose increase. Discuss with your doctor if you have heart conditions or are dehydrated.

• Increased Prolactin Levels: Elevated prolactin levels can result in fertility issues, breast changes, sexual dysfunction, irregular menstrual periods, and bone weakness. Regular blood tests may be necessary to monitor prolactin levels.

• Infection Risk: The medication may lower white blood cell counts, increasing infection risk. Regular monitoring may be required. Contact your healthcare provider immediately if you experience fever, weakness, or sore throat.

• Intestinal Concerns: Invega's non-dissolving outer shell could cause blockages in those with gastrointestinal issues like inflammatory bowel disease. Inform your provider if you have any gut-related conditions.

• Heart Rhythm Changes (QT Prolongation): Use caution if you have low potassium or magnesium levels, are older, female, have a history of heart problems, or are taking other QT-prolonging medications.

Contraindications:

• Do not use Invega if you have a known allergy to risperidone (Risperdal).

In the event of an overdose, seek emergency medical assistance immediately. Always discuss any other medications or substances you are using with your healthcare provider to avoid adverse interactions.

When taking this medication, you might experience some common side effects like drowsiness, dizziness, lightheadedness, drooling, stomach or abdominal pain, and weight gain. It's important to get up slowly from sitting or lying positions to prevent dizziness and reduce the risk of falling. Some individuals may also notice an empty tablet shell in their stool, which is harmless.

While many people do not experience serious side effects, it is crucial to be aware of them. Potential serious side effects include difficulty swallowing, muscle spasms, tremors, and changes in mood or mental state. This medication may also affect blood sugar levels, potentially leading to or worsening diabetes. Be on the lookout for increased thirst or urination, and if you have diabetes, monitor your blood sugar levels closely. Additionally, weight gain and increases in cholesterol or triglyceride levels could heighten the risk of heart disease.

Rare but serious conditions such as tardive dyskinesia, involving unusual or uncontrolled movements, or neuroleptic malignant syndrome, characterized by fever, muscle stiffness, confusion, or changes in heart rate and blood pressure, require immediate medical attention. Males should seek urgent care if they experience a prolonged erection lasting over four hours, as this can lead to permanent issues.

An increase in prolactin levels may cause specific symptoms such as unwanted breast milk production, menstrual irregularities, or fertility issues in females, and decreased sexual ability or breast enlargement in males. Lastly, seek medical help for severe side effects like seizures, severe dizziness, fainting, or any signs of a serious allergic reaction such as rash, swelling, or difficulty breathing. Always contact your healthcare provider if you notice any worrying symptoms.

When taking Invega (paliperidone), it's important to be aware of potential interactions with other medications. Inform your doctor or pharmacist about all drugs and supplements you are currently using, including over-the-counter and herbal products.

Some medications, such as metoclopramide, should not be used with Invega. Your doctor might avoid prescribing these together or adjust your treatment plan. Other drugs, like amiodarone, chlorpromazine, and moxifloxacin, can affect heart rhythm (QT prolongation) and should be used with caution under a doctor's supervision. Additionally, medications causing drowsiness, such as opioid pain relievers (e.g., codeine, hydrocodone), alcohol, marijuana, sleep aids (e.g., alprazolam, lorazepam, zolpidem), muscle relaxants (e.g., carisoprodol, cyclobenzaprine), and antihistamines (e.g., cetirizine, diphenhydramine), may increase side effects when combined with Invega. Always check medication labels for drowsiness-causing ingredients and consult your pharmacist for guidance.

Furthermore, let your healthcare provider know if you're taking medications known to prolong QT interval, including quinidine, sotalol, and procainamide, as well as any products that may cause drowsiness. They may need to adjust your treatment to prevent adverse effects.