Caplyta

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This medication is used to treat certain mental/mood disorders (such as schizophrenia, episodes of depression associated with bipolar disorder). Lumateperone belongs to a class of drugs known as atypical antipsychotics. It works by helping to restore the balance of certain natural substances in the brain.
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10.5MG, Caplyta (30 Capsules)

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CVS

$1720.60

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$1639.87

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$1755.93

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$1766.92

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CVS

$1720.60

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Warnings

There may be a slightly increased risk of serious, possibly fatal side effects (such as stroke, heart failure, fast/irregular heartbeat, pneumonia) when this medication is used by older adults with dementia. This medication is not approved for the treatment of dementia-related behavior problems. Discuss the risks and benefits of this medication, as well as other effective and possibly safer treatments for dementia-related behavior problems, with the doctor. Lumateperone is used to treat certain mental/mood disorders (such as schizophrenia, episodes of depression associated with bipolar disorder). Drugs used to treat depression can help prevent suicidal thoughts/attempts and provide other important benefits. However, studies have shown that a small number of people (especially people younger than 25) who take drugs to treat depression may experience worsening depression, other mental/mood symptoms, or suicidal thoughts/attempts. It is very important to talk with the doctor about the risks and benefits of drugs used to treat depression (especially for people younger than 25), even if treatment is not for a mental/mood condition. Tell the doctor right away if you notice worsening depression/other psychiatric conditions, unusual behavior changes (including possible suicidal thoughts/attempts), or other mental/mood changes (including new/worsening anxiety, panic attacks, trouble sleeping, irritability, hostile/angry feelings, impulsive actions, severe restlessness, very rapid speech). Be especially watchful for these symptoms when a new drug to treat depression is started or when the dose is changed.

Caplyta Side Effects

Drowsiness, dizziness, lightheadedness, dry mouth, or nausea may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Dizziness and lightheadedness can increase the risk of falling. Get up slowly when rising from a sitting or lying position. Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Tell your doctor right away if you have any serious side effects, including: difficulty swallowing, interrupted breathing during sleep (sleep apnea), signs of infection (such as sore throat that doesn't go away, fever, chills). This medication may rarely make your blood sugar rise, which can cause or worsen diabetes. Tell your doctor right away if you have symptoms of high blood sugar such as increased thirst/urination. If you already have diabetes, check your blood sugar regularly as directed and share the results with your doctor. Your doctor may need to adjust your diabetes medication, exercise program, or diet. This drug may also cause significant weight gain and a rise in your blood cholesterol (or triglyceride) levels. These effects, along with diabetes, may increase your risk for developing heart disease. Discuss the risks and benefits of treatment with your doctor. (See also Notes section.) Lumateperone may rarely cause a condition known as tardive dyskinesia. In some cases, this condition may be permanent. Tell your doctor right away if you develop any unusual/uncontrolled movements (especially of the face, lips, mouth, tongue, arms or legs). Get medical help right away if you have any very serious side effects, including: seizures. This medication may rarely cause a very serious condition called neuroleptic malignant syndrome (NMS). Get medical help right away if you have any of the following symptoms: fever, muscle stiffness/pain/tenderness/weakness, severe tiredness, severe confusion, sweating, fast/irregular heartbeat, dark urine, signs of kidney problems (such as change in the amount of urine). A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. In the US - Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Interactions

A product that may interact with this drug is: metoclopramide. Other medications can affect the removal of lumateperone from your body, which may affect how lumateperone works. Examples include rifamycins (such as rifabutin), St. John's wort, drugs used to treat seizures (such as carbamazepine, phenytoin), among others. Tell your doctor or pharmacist if you are taking other products that cause drowsiness such as opioid pain or cough relievers (such as codeine, hydrocodone), alcohol, marijuana (cannabis), drugs for sleep or anxiety (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or antihistamines (such as cetirizine, diphenhydramine). Check the labels on all your medicines (such as allergy or cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.
Caplyta FAQs
Is Caplyta a mood stabilizer or antipsychotic?

Caplyta (lumateperone) is classified as an atypical antipsychotic. It is primarily used to treat schizophrenia and bipolar depression.

The effectiveness of Caplyta (lumateperone) versus Abilify (aripiprazole) can vary depending on the individual and the specific condition being treated. Both medications are used to treat mental health conditions, but they have different mechanisms of action and side effect profiles. Caplyta is primarily used for the treatment of schizophrenia and bipolar depression, while Abilify is used for a broader range of conditions, including schizophrenia, bipolar disorder, and as an adjunct for major depressive disorder. The choice between these medications should be based on a thorough evaluation by a healthcare provider, considering the patient's specific symptoms, medical history, and potential side effects. It is important for patients to discuss with their healthcare provider to determine which medication may be more suitable for their individual needs.

Mood stabilizers and antipsychotics are both classes of medications used to treat mental health conditions, but they have different primary uses and mechanisms of action.Mood stabilizers are primarily used to treat mood disorders, such as bipolar disorder. They help to stabilize mood swings, preventing episodes of mania and depression. Common mood stabilizers include lithium and certain anticonvulsants like valproate and lamotrigine.Antipsychotics, on the other hand, are primarily used to treat psychotic disorders, such as schizophrenia. They help manage symptoms like hallucinations, delusions, and thought disorders. Antipsychotics can also be used as adjunctive treatments in mood disorders. They are divided into typical (first-generation) and atypical (second-generation) antipsychotics, with examples including haloperidol and risperidone, respectively.While there is some overlap in their use, particularly in the treatment of bipolar disorder, their primary indications and mechanisms differ.

Caplyta (lumateperone) is not typically associated with weight loss. In fact, weight gain is a more common side effect observed in some patients taking Caplyta. However, individual responses to medication can vary, and any concerns about weight changes should be discussed with a healthcare provider.

Antipsychotics can have varying effects on appetite, depending on the specific medication. Some antipsychotics may increase appetite and lead to weight gain, while others might have a neutral or even appetite-suppressing effect. It's important for individuals to discuss any concerns about appetite changes with their healthcare provider, as they can provide guidance tailored to the specific medication and individual needs.