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Lumateperone is prescribed for the management of certain mental and mood disorders, such as schizophrenia and depressive episodes linked to bipolar disorder. While these medications can offer significant benefits, including reducing the risk of suicidal thoughts and attempts, they also come with potential risks, particularly for specific groups.

• Risks for Older Adults with Dementia: There is an elevated risk of severe, possibly life-threatening side effects—including stroke, heart failure, irregular heartbeat, and pneumonia—when this medication is administered to older adults with dementia. It is not approved for addressing dementia-related behavior issues. Engage in a detailed discussion with your healthcare provider about the risks and benefits, as well as alternative treatment options that might be safer for managing dementia-related behavior.

• Considerations for Younger Individuals: Studies indicate that a small percentage of individuals, particularly those under 25, might experience worsening depression, new or aggravated mental/mood symptoms, or suicidal thoughts or attempts when taking depression-related medications. It is crucial to weigh the risks and benefits of these drugs with your healthcare provider, especially for younger individuals, even if the medication is not being used for a mental/mood disorder.

• Monitoring and Reporting Symptoms: Immediately contact a healthcare professional if you observe signs of worsening depression or other psychiatric conditions, unusual behavioral changes (including potential suicidal thoughts or attempts), or other mental/mood changes. These can include new or worsening anxiety, panic attacks, difficulty sleeping, irritability, hostile or angry feelings, impulsive actions, severe restlessness, or very rapid speech. Pay particular attention to these symptoms when starting a new depression medication or adjusting the dosage.

In case of any concerning symptoms or in the event of an overdose, seek immediate medical attention. Always communicate openly with your healthcare provider about any changes or concerns regarding your treatment plan.

When taking this medication, some people may experience mild side effects such as drowsiness, dizziness, lightheadedness, dry mouth, or nausea. These are generally not serious but should be reported if they persist or worsen. To minimize dizziness or lightheadedness, it's advisable to rise slowly from sitting or lying down to prevent falls.

More serious side effects, although less common, require immediate attention. These include difficulty swallowing, sleep apnea, and signs of infection like persistent sore throat, fever, or chills. The medication may also cause an increase in blood sugar levels, which could lead to or worsen diabetes. It is important to monitor for symptoms like increased thirst or urination and to check blood sugar levels regularly if you have diabetes.

Weight gain and elevated cholesterol or triglyceride levels can occur, potentially increasing the risk of heart disease. Discussing these risks with your healthcare provider is important. Rarely, the drug can lead to tardive dyskinesia, a potentially permanent condition characterized by unusual or uncontrolled movements, particularly of the face and limbs.

Seek medical help immediately if you experience seizures or symptoms of neuroleptic malignant syndrome (NMS), such as fever, muscle stiffness, severe confusion, or signs of kidney problems. Although a severe allergic reaction is rare, it is crucial to get medical attention if you notice rash, swelling, severe dizziness, or trouble breathing. Always report any new or worsening symptoms to your healthcare provider.