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Latuda (lurasidone) is utilized in treating certain mental health conditions, including schizophrenia and bipolar disorder-related depression. It is crucial to be aware of the potential risks and precautions associated with its usage. Below are important safety details to consider:

• Risks for Older Adults with Dementia-Related Psychosis: Individuals over 65 with dementia-related psychosis should not use Latuda (lurasidone) due to a heightened risk of serious side effects like stroke, heart problems, and infections. Discuss alternative treatments with a healthcare provider.

• Depression and Suicidal Thoughts: This medication may worsen depression and lead to suicidal thoughts, especially in individuals under 25, during initial treatment months or with dosage changes. Immediate medical attention is necessary if these symptoms emerge.

• Neuroleptic Malignant Syndrome: A rare but life-threatening condition, neuroleptic malignant syndrome, can occur with Latuda (lurasidone). Symptoms include fever, muscle stiffness, confusion, and irregular heartbeat. Seek urgent medical care if these occur.

• Tardive Dyskinesia: Long-term use may result in uncontrollable muscle movements. The risk increases with higher doses and prolonged use. Report any unusual muscle movements to your healthcare provider promptly.

• Metabolic Changes: Latuda (lurasidone) can alter weight, blood sugar, and cholesterol. Routine blood tests might be necessary to monitor these changes. Maintain a healthy diet and exercise routine.

• High Prolactin Levels: Elevated prolactin levels can lead to symptoms such as nipple discharge or menstrual irregularities. Consult your provider if these occur.

• Blood Pressure and Fall Risk: This medication may cause low blood pressure and dizziness, increasing fall risk. Stand up slowly from sitting or lying positions and report any falls to your provider.

• Infection Risk: Latuda (lurasidone) may reduce white blood cell count, raising infection risk. Regular blood tests may be required. Seek medical help for persistent fever, fatigue, or breathing difficulties.

• Drowsiness and Concentration Issues: The medication can cause significant drowsiness and impair concentration. Avoid driving or operating machinery until you know how Latuda (lurasidone) affects you.

• Seizure Risk: Inform your provider of any history of seizures or conditions that might increase seizure susceptibility before starting Latuda (lurasidone).

• Manic Episodes in Bipolar Disorder: Rarely, the medication may induce manic episodes in bipolar disorder. Report any drastic behavioral changes to your provider.

• Nervous System Effects in Parkinson’s or Lewy Body Dementia: Those with these conditions may experience heightened sensitivity and symptoms like confusion or movement issues. Immediate medical evaluation is advised if these symptoms appear.

Contraindications: Avoid using Latuda (lurasidone) if taking medications known to interact negatively, such as ritonavir, phenytoin, carbamazepine, rifampin, or St. John's wort. Always consult with your healthcare provider regarding any potential interactions and health conditions before starting treatment.

When taking this medication, you may experience some common side effects, which are typically mild and manageable. These include drowsiness, nausea, dizziness, lightheadedness, and difficulty moving or staying still. Occasionally, you might notice some stomach upset, such as pain, diarrhea, or vomiting, as well as a decrease in appetite or blurred vision. If these symptoms persist or worsen, it's advisable to consult a healthcare provider.

In some cases, more serious side effects may occur, which require immediate medical attention. These include severe dizziness or lightheadedness, drooling, trouble swallowing, or fainting. Rarely, you might experience uncontrollable movements, known as tardive dyskinesia, which could become permanent. High blood sugar levels, leading to symptoms like increased thirst or urination, or elevated blood fat levels may also occur. For some, there is a risk of a serious condition called neuroleptic malignant syndrome, characterized by fever, muscle stiffness, or confusion.

Additionally, a rise in prolactin levels may result in symptoms such as unwanted breast milk production, menstrual changes, or fertility issues in females, and decreased sexual ability or enlarged breasts in males. Rare side effects like prolonged or painful erections in males and severe allergic reactions, such as rash or trouble breathing, are also possible. In very rare instances, individuals may experience seizures, stroke symptoms, serious infections, or suicidal thoughts. If you notice any of these serious side effects, seek medical help immediately.

Lurasidone, marketed as Latuda, can interact with a variety of other medications and substances, potentially affecting its effectiveness and safety. It is crucial to inform your doctor and pharmacist about all medications and supplements you are taking, including prescription, over-the-counter, vitamins, and herbal products.

Certain medications may interfere with how lurasidone is processed in your body. These include drugs like cobicistat, diltiazem, ritonavir, telithromycin, azole antifungals (e.g., ketoconazole, itraconazole), HIV protease inhibitors (e.g., nelfinavir), macrolide antibiotics (e.g., clarithromycin), rifamycins (e.g., rifampin, rifabutin), and some antidepressants (e.g., fluoxetine, paroxetine, nefazodone).

Additionally, medications such as boceprevir, bromopride, carbamazepine, conivaptan, darunavir, enzalutamide, fosphenytoin, idelalisib, indinavir, lopinavir, metoclopramide, phenytoin, posaconazole, primidone, rifapentine, saquinavir, St John's Wort, telaprevir, tipranavir, and voriconazole should generally be avoided while taking lurasidone. Your doctor might opt for different treatment options if you're using any of these.

There are also medications that, while usually not recommended, may need to be used simultaneously with lurasidone. In such cases, your healthcare provider might adjust the dosage or administration frequency. These medications include abiraterone acetate, amprenavir, aprepitant, atazanavir, buprenorphine, ceritinib, ciprofloxacin, crizotinib, delavirdine, duvelisib, erythromycin, fluconazole, fosamprenavir, fosaprepitant, fosnetupitant, imatinib, ivosidenib, larotrectinib, lefamulin, letermovir, lorlatinib, lumacaftor, methadone, netupitant, remifentanil, and verapamil.

Additionally, be cautious about using substances that can cause drowsiness, such as opioid pain relievers (e.g., codeine, hydrocodone), alcohol, marijuana, and certain drugs for sleep or anxiety (e.g., alprazolam, lorazepam, zolpidem), muscle relaxants (e.g., carisoprodol, cyclobenzaprine), or antihistamines (e.g., cetirizine, diphenhydramine). Always check with your pharmacist on how to safely use all your medications, including those for allergies or colds, as they might contain ingredients that can increase dizziness or drowsiness.