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The following information outlines essential safety precautions and warnings related to the use of Jardiance (empagliflozin). It is crucial to thoroughly review this content and consult with your healthcare provider if you have any questions or concerns.

• Ketoacidosis Risk: Jardiance may lead to a severe condition known as ketoacidosis, characterized by an excess of ketones causing blood acidity. This risk is heightened for individuals with diabetes who are experiencing illness, reduced caloric intake, recent surgery, dehydration, pancreatic issues, or are on a ketogenic diet. Additionally, alcohol consumption and missed or altered insulin doses can increase this risk.

• Dehydration and Low Blood Pressure: The medication can reduce body fluid levels, potentially causing dehydration and low blood pressure. This effect can impair kidney blood flow, potentially leading to kidney damage. Individuals over 65, those with kidney issues, or those on loop diuretics or low-sodium diets are at increased risk.

• Genital and Urinary Tract Infections: Jardiance may elevate the likelihood of developing genital infections, such as yeast infections, and urinary tract infections (UTIs). Symptoms to watch for include painful urination, frequent urination, blood in urine, unusual genital odor, or genital discomfort. Prompt medical attention is advised if these symptoms occur, especially for those with a history of such infections.

• Hypoglycemia: When used with other diabetes medications like insulin or sulfonylureas (e.g., glipizide), Jardiance may cause dangerously low blood sugar levels. Risks increase with dietary and exercise changes, alcohol consumption, and for children.

• Leg and Foot Amputations: Although uncommon, some users have required amputations of the leg or foot during clinical trials. The risk is particularly elevated for individuals with a history of amputation, blood circulation issues, peripheral artery disease, or diabetic foot ulcers.

• Allergic Reactions: Serious allergic reactions to Jardiance can occur, though they are rare. Emergency medical attention is necessary if symptoms such as difficulty breathing, rash, or swelling of the face, lips, tongue, or throat occur.

Please consult your healthcare provider for personalized advice and to ensure this medication is safe for your use given your health history and any other medications you may be taking.

When taking this medication, you may experience some common side effects like frequent urination, dizziness, or lightheadedness. These effects are generally mild but should be reported to your healthcare provider if they persist or worsen. To minimize dizziness or lightheadedness, try rising slowly from sitting or lying positions. Additionally, you might encounter urinary tract infections, vaginal yeast infections in women, or genital yeast infections in men, which are more common but usually manageable with medical advice.

Some individuals report increased thirst, joint pain, nausea, and high cholesterol or fat levels. While these are generally mild, persistent symptoms should be discussed with your healthcare provider. Upper respiratory tract infections have also been reported but are not overly concerning in most cases.

More severe side effects, though rare, demand immediate medical attention. These include signs of a urinary tract infection, kidney problems, unusual tiredness, nausea, vomiting, stomach pain, or breathing difficulties. There is also a risk of a severe allergic reaction, characterized by swelling of the face, throat, tongue, or mouth, rash, or trouble breathing. Additionally, high ketone levels in the blood, which can cause nausea, vomiting, stomach pain, and fruity breath, require urgent care.

The medication may increase the risk of lower limb amputation, especially if you have existing foot issues. Regular foot checks and reporting new pain or sores to your doctor can help manage this risk. Dehydration is another serious concern, so maintaining adequate fluid intake is vital. Symptoms like decreased urination, dry mouth, and dizziness indicate dehydration and should be promptly addressed.

Lastly, while this medication does not usually cause low blood sugar, it can occur if combined with other diabetes treatments or insufficient caloric intake. Recognizing symptoms such as sudden sweating, shaking, and fast heartbeat is important. Carrying glucose tablets or gel can help manage low blood sugar episodes effectively.