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This medication comes with several important safety warnings and precautions. Please read them thoroughly and discuss any concerns with your healthcare provider.

• Ketoacidosis Risk: Brenzavvy (bexagliflozin) may cause ketoacidosis, a severe condition where the body produces excessive ketones, leading to acidic blood. This risk increases if you have diabetes, are unwell, consume fewer calories, drink excessively, have had surgery, or have reduced your insulin dose. Symptoms include dry mouth, fruity-smelling breath, fatigue, nausea, vomiting, stomach pain, and difficulty breathing. In such cases, discontinue use and seek immediate medical attention.

• Lower Limb Amputation: There is a rare but increased risk of foot or leg amputations with Brenzavvy (bexagliflozin). This risk is higher for individuals with a history of amputation, blood circulation issues, or nerve problems. Pay attention to any new pain, tenderness, sores, ulcers, or infections in the legs or feet and report them to your healthcare provider. Regular foot exams are recommended.

• Dehydration and Low Blood Pressure: This medication can cause dehydration, low blood pressure, or kidney damage, particularly if you have pre-existing kidney issues, are over 65, follow a low-sodium diet, or take loop diuretics. Ensure adequate hydration and consult your provider if you experience dizziness, reduced urination, vomiting, or diarrhea.

• Genital and Urinary Tract Infections: Brenzavvy (bexagliflozin) increases the risk of genital and urinary tract infections, which can become severe. Contact your healthcare provider if you have a burning sensation during urination, frequent urination, lower abdominal pain, blood in urine, genital odor, or any pain, itching, swelling, redness, or tenderness around the genitals.

• Hypoglycemia with Other Diabetes Medications: The risk of low blood sugar is higher when Brenzavvy (bexagliflozin) is taken with other diabetes medications like insulin or sulfonylureas. Symptoms of low blood sugar include nervousness, shakiness, fatigue, confusion, rapid heartbeat, sweating, and extreme hunger. Monitor your blood sugar closely if these symptoms occur.

Contraindications: Do not use this medication if you are on dialysis, as it may pose serious health risks. Always consult with your healthcare provider to ensure safety.

When taking this medication, you might experience common side effects such as frequent urination, dizziness, or lightheadedness. These effects are generally mild but consult your healthcare provider if they persist or worsen. To minimize dizziness, try rising slowly from sitting or lying down. Additionally, some individuals may notice increased thirst or develop a urinary tract infection.

More concerning side effects include signs of a urinary tract infection, such as painful urination or pink urine, and indications of kidney problems like swollen legs or changes in urination. Bone pain should also be reported. This medication may cause vaginal or penile yeast infections, characterized by unusual discharge, burning, itching, or odor. In rare cases, it can lead to a severe bacterial infection known as Fournier's gangrene. Seek immediate medical help if you experience pain or swelling in the genital area accompanied by fever.

There is an increased risk of lower limb amputation, particularly if you have poor blood flow, nerve issues, or foot ulcers. Regularly check your feet and report new pain or sores. Low blood sugar is uncommon unless combined with other diabetes medications or insufficient caloric intake. Symptoms include sweating, fast heartbeat, and dizziness. Keep glucose tablets handy to manage this.

The medication can cause dehydration, potentially leading to kidney damage. Ensure adequate fluid intake and notify your doctor if you experience dehydration symptoms like dry mouth or rapid heartbeat. Serious allergic reactions, though rare, require immediate attention if you notice swelling, rash, or breathing difficulties. Always contact your healthcare provider for any side effects not listed here.