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Etodolac is a nonsteroidal anti-inflammatory drug (NSAID) used to manage pain and inflammation. However, its use comes with important safety considerations and potential risks. Please review the following information carefully and discuss any concerns with your healthcare provider.

• Heart Attack and Stroke Risk: Etodolac may increase the likelihood of heart attack or stroke, especially with prolonged use. This risk is heightened in individuals with pre-existing heart conditions or those who smoke or have diabetes. Avoid using etodolac immediately before or after heart bypass surgery (CABG).

• Stomach and Intestinal Bleeding: This medication can cause severe, potentially fatal bleeding in the stomach or intestines without warning signs. The risk is greater in older adults and those with a history of stomach issues or who consume alcohol and smoke.

• High Blood Pressure and Heart Failure: Etodolac may cause fluid retention, leading to elevated blood pressure or heart failure. Notify your doctor if you have heart conditions or are on blood pressure medication before starting etodolac.

• Kidney Damage: Long-term use of etodolac can harm the kidneys, with increased risk in older adults and those with pre-existing kidney problems or who use diuretics. Watch for symptoms like changes in urination, fatigue, or muscle cramps.

• Liver Issues: Etodolac has been linked to rare cases of liver damage. Seek immediate medical attention if you experience symptoms such as stomach swelling, yellowing of the skin or eyes, or dark urine.

• Allergic Reactions: Severe allergic reactions, including anaphylaxis, are possible. If you have allergies to aspirin or other NSAIDs, inform your healthcare provider. Immediate medical help is needed if you experience hives, facial swelling, or breathing difficulties.

• Pregnancy Concerns: Etodolac is not recommended during pregnancy, particularly after the 20th week, due to potential risks to the unborn child.

• Bleeding Risks: The medication may increase bleeding tendencies, especially when taken with blood thinners or certain antidepressants. Inform your doctor if you have a history of bleeding disorders.

Contraindications: Do not use etodolac if you have experienced asthma, hives, or other allergic reactions to aspirin or NSAIDs. It is also contraindicated after coronary artery bypass graft surgery.

In case of an overdose, seek emergency medical assistance immediately. Always discuss the benefits and risks of etodolac with your healthcare provider to ensure safe and effective use.

When taking this medication, you might experience some common side effects, which are usually mild. These include an upset stomach, nausea, diarrhea, gas, drowsiness, dizziness, and blurred vision. If any of these persist or worsen, it is advisable to consult your healthcare provider for further guidance.

There are also some other side effects reported by users, such as stomach pain, indigestion, vomiting, constipation, headache, and ringing in the ears. In some cases, individuals may also experience itching, rash, anemia, and elevated liver enzymes. Though these effects can be concerning, they are often manageable with appropriate care.

More serious side effects, while rare, require immediate medical attention. These include symptoms of stomach bleeding, such as feeling faint, vomiting blood, or having bloody stools. Additionally, signs of a heart attack or stroke, like chest pain or slurred speech, should be treated as emergencies. Heart failure symptoms, liver problems like yellowing skin or dark urine, and kidney issues such as reduced urine output also warrant urgent care.

Lastly, be aware of any severe allergic reactions, which may present as hives, skin reddening, swelling of the lips or tongue, or difficulty breathing. Prompt medical help is crucial if these occur. Always communicate with your healthcare provider about any unexpected effects for the best management of your health.

When using Etodolac, it is important to be aware of potential interactions with other medications. Certain drugs, such as aliskiren, ACE inhibitors (e.g., benazepril, lisinopril), angiotensin II receptor blockers (e.g., losartan, valsartan), cidofovir, corticosteroids (e.g., dexamethasone, prednisone), lithium, methotrexate, and diuretics like furosemide, may interact with Etodolac. Additionally, combining Etodolac with medications that increase bleeding risk, such as anti-platelet drugs like clopidogrel and blood thinners like dabigatran, enoxaparin, or warfarin, can elevate the likelihood of bleeding.

It's crucial to review all prescription and non-prescription medicine labels for pain relievers or fever reducers, particularly those containing aspirin or NSAIDs like ibuprofen, ketorolac, or naproxen, as they resemble Etodolac and may heighten side effects when taken together. However, if prescribed low-dose aspirin for heart attack or stroke prevention, continue its use unless advised otherwise by your doctor.

Etodolac may also affect certain lab tests, leading to inaccurate results, so inform your healthcare providers, including your lab personnel, about its use.

Always consult with your doctor or pharmacist about any medications, including over-the-counter drugs, vitamins, and herbal supplements, to prevent interactions. Your healthcare provider may need to adjust dosages or treatment plans based on these interactions.