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Etodolac is a nonsteroidal anti-inflammatory drug (NSAID) that may carry certain risks and requires careful consideration before use. Below are important safety warnings and precautions to be aware of:

• Increased Risk of Heart Attack and Stroke: Etodolac may elevate the risk of heart attacks or strokes, especially with prolonged use or in individuals with pre-existing heart conditions. This risk is heightened if you've had heart surgery or plan to undergo one. Avoid taking etodolac immediately before or after coronary artery bypass graft (CABG) surgery.

• Stomach and Intestinal Bleeding: The use of etodolac can lead to serious, potentially fatal bleeding in the stomach or intestines without warning symptoms. This risk is more pronounced in older adults and those with a history of stomach bleeding or liver conditions. Inform your healthcare provider about all your medical conditions and medications to assess your risk.

• High Blood Pressure and Heart Failure: Etodolac may cause fluid retention, leading to increased blood pressure or potential heart failure. Discuss your medical history with your healthcare provider, particularly if you have heart conditions or are on blood pressure medications.

• Kidney Damage: Long-term use of etodolac can harm the kidneys, particularly in older adults and those with pre-existing kidney or liver conditions. Monitor for symptoms such as changes in urination, fatigue, and muscle cramps, and contact your healthcare provider if they occur.

• Liver Problems: There have been reports of elevated liver enzymes and serious liver damage in individuals taking etodolac. Seek immediate medical attention if you experience symptoms like yellowing of the skin or eyes, dark urine, or severe abdominal pain, as these may indicate liver damage.

• Severe Allergic Reactions: Allergic reactions, including life-threatening ones, can occur with etodolac. If you have a history of allergies to aspirin or other NSAIDs, or if you have asthma, inform your healthcare provider. Seek emergency help if you develop hives, facial swelling, or difficulty breathing.

• Pregnancy Warning: Etodolac can cause harm to an unborn baby, particularly after the 20th week of pregnancy. Discuss the risks and benefits with your healthcare provider if you are pregnant or planning to become pregnant.

• Increased Bleeding Risk: Taking etodolac can increase bleeding risks, especially if used with blood thinners like aspirin or warfarin, or with certain antidepressants. Notify your healthcare professional if you experience unusual bleeding.

Contraindications: Do not use etodolac if you have a history of asthma, hives, or other allergic reactions to NSAIDs, or if you're undergoing or have had CABG surgery.

In case of overdose, seek immediate medical attention. Always discuss with your healthcare provider the potential benefits and risks of taking etodolac to ensure it is appropriate for your condition.

Common side effects:

• upset stomach
• nausea
• diarrhea
• gas
• drowsiness
• dizziness
• blurred vision
• headaches
• indigestion
• itching
• rash
• mild swelling

Serious side effects:

• stomach bleeding
• heart attack
• stroke
• heart failure
• liver problems
• kidney problems
• allergic reaction

Interactions with high risk of serious adverse effects and should be avoided:

• Ketorolac

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Aliskiren
• ACE inhibitors (such as Benazepril, Lisinopril)
• Angiotensin II receptor blockers (such as Losartan, Valsartan)
• Cidofovir
• Corticosteroids (such as Dexamethasone, Prednisone)
• Lithium
• Methotrexate
• Diuretics (such as Furosemide)
• Anti-platelet drugs (such as Clopidogrel)
• Blood thinners (such as Dabigatran, Enoxaparin, Warfarin)
• Aspirin
• Ibuprofen
• Naproxen