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This medication may lead to common side effects such as drowsiness, dizziness, headache, blurred vision, upset stomach, nausea, constipation, and a dry mouth, nose, or throat. These effects are usually mild and manageable. To alleviate dry mouth, consider using sugarless candy, ice chips, or gum, and drink plenty of water. Staying hydrated can also help reduce mucus thickness in the lungs, which might make breathing easier. To minimize dizziness or lightheadedness, rise slowly from sitting or lying positions.

While most users do not experience severe side effects, it's important to be aware of them. Serious side effects that require prompt medical attention include mental or mood changes like confusion or hallucinations, ringing in the ears, tremors, difficulty urinating, unusual weakness, easy bruising or bleeding, irregular heartbeat, or seizures.

Though rare, an allergic reaction to this medication is serious. Seek immediate medical help if you experience symptoms such as a rash, itching, swelling (particularly of the face, tongue, or throat), severe dizziness, or trouble breathing. Always consult with a healthcare professional if you notice any other unusual effects.

It is crucial to avoid taking this medication alongside certain MAO inhibitors, as this may lead to a severe and potentially life-threatening reaction. Specifically, do not use isocarboxazid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, or tranylcypromine while on this medication. Additionally, most MAO inhibitors should not be used within two weeks before or after treatment with this drug. Consult your doctor regarding when to safely start or stop these medications.

Be aware that some products may interact with this medication, including skin-applied antihistamines like diphenhydramine cream, ointment, or spray, as well as rolapitant. Inform your doctor or pharmacist if you are using other substances that induce drowsiness, such as opioid pain or cough medications (e.g., codeine, hydrocodone), alcohol, marijuana, sleep or anxiety medications (e.g., alprazolam, lorazepam, zolpidem), muscle relaxants (e.g., carisoprodol, cyclobenzaprine), or any other antihistamines (e.g., cetirizine, diphenhydramine).

Check the labels on all your medications, particularly those for allergies or cough-and-cold, as they may contain ingredients that can cause drowsiness. Always consult your pharmacist to ensure safe usage of these products.

This medication may also affect certain medical or laboratory tests, such as brain scans for Parkinson's disease, urine drug screenings, and allergy skin tests, potentially leading to incorrect results. Ensure all your healthcare providers and lab technicians are aware that you are taking this medication.