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Polytussin DM is a medication used to treat symptoms such as cough and congestion. It is important to be aware of specific safety warnings and precautions when using this medication to avoid potential risks and adverse effects. Below is a clear and concise summary of the key safety information:

• Serotonin Syndrome Risk: Polytussin DM contains dextromethorphan, which can increase the risk of serotonin syndrome, a rare but serious condition. This risk is heightened if you are also taking other drugs that affect serotonin levels, such as certain antidepressants, MAOIs, or migraine medications. Avoid using Polytussin DM if you have taken an MAOI in the last 14 days.

• Accidental Overdose: The combination of active ingredients in Polytussin DM, which includes a cough suppressant, a decongestant, and an antihistamine, can lead to an accidental overdose if combined with other medications containing similar substances. This could have life-threatening consequences.

• Pre-existing Medical Conditions: Before using Polytussin DM, inform your healthcare provider and pharmacist about any pre-existing medical conditions. This medication may exacerbate certain conditions, including:

  • Breathing difficulties
  • Glaucoma
  • Urinary issues
  • Cough associated with smoking, asthma, or emphysema
  • Coughs that produce mucus
  • Heart disease or hypertension

• Contraindications: If you are currently using or have recently used a monoamine oxidase inhibitor (MAOI) within the past two weeks, you should not take Polytussin DM. This combination can pose serious health risks.

Please consult your healthcare provider for further guidance and to ensure that Polytussin DM is safe for you. In case of an overdose, seek emergency medical attention immediately.

When taking this medication, you might experience some common side effects such as drowsiness, dizziness, headache, blurred vision, upset stomach, nausea, constipation, and dry mouth, nose, or throat. These effects are generally mild and may improve over time. To alleviate dry mouth, you can chew sugarless gum or candy, drink water, or use a saliva substitute. If you feel dizzy or lightheaded, try getting up slowly from sitting or lying positions.

In some cases, individuals may encounter trouble sleeping or trouble urinating. If these effects persist or worsen, it is advisable to consult your healthcare provider. Although many people do not experience serious side effects, you should be aware of them. Serious side effects, though rare, include mental or mood changes like confusion or hallucinations, ringing in the ears, tremors, weakness, easy bruising or bleeding, irregular heartbeat, and seizures. Serotonin syndrome, a serious condition, may present with symptoms like a fast heart rate, sweating, muscle stiffness, high fever, and confusion.

Allergic reactions to this medication are very rare but require immediate medical attention. Symptoms can include rash, itching or swelling, severe dizziness, and trouble breathing. Always contact your healthcare provider if you notice any new or worsening symptoms.

It is crucial to avoid taking certain MAO inhibitors with this medication, as it may lead to a serious, potentially life-threatening interaction. Specifically, do not use isocarboxazid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, or tranylcypromine while on this medication. Furthermore, refrain from using most MAO inhibitors for two weeks before and after your treatment. Consult your doctor for guidance on when to start or stop this medication.

Additionally, some products may interact with this medication, including skin-applied antihistamines like diphenhydramine cream, ointment, or spray, and the drug rolapitant. Inform your healthcare provider if you are using other products that can cause drowsiness, such as opioid pain relievers (like codeine and hydrocodone), alcohol, marijuana, sleep or anxiety medications (such as alprazolam, lorazepam, zolpidem), muscle relaxants (such as carisoprodol, cyclobenzaprine), or other antihistamines (such as cetirizine, diphenhydramine).

Be sure to check the labels on all your medications, including those for allergies or cough and cold, as they may contain ingredients that induce drowsiness. Consult your pharmacist for advice on using these products safely. Additionally, this medication can interfere with certain medical or laboratory tests, such as brain scans for Parkinson's disease, urine drug screenings, and allergy skin tests, potentially leading to false results. Ensure that all medical personnel and your doctors are aware you are taking this medication.