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This document outlines important safety information and warnings related to the use of Gemfibrozil (Lopid). It is essential to read these details carefully and discuss any concerns with your healthcare provider.

• Gallstones: Gemfibrozil (Lopid) may lead to the formation of gallstones. Contact your healthcare provider immediately if you notice symptoms such as stomach, back, or shoulder pain, nausea, vomiting, or yellowing of the skin or eyes. Avoid using Gemfibrozil if you have a history of gallbladder issues.

• Drug Interactions: Gemfibrozil (Lopid) can interact with other medications, which may lead to serious consequences. Notify your healthcare provider or pharmacist if you are concurrently taking the blood thinner warfarin (Coumadin), as Gemfibrozil may increase the risk of bleeding. Regular blood monitoring is advised.

• Muscle Damage: There is a potential risk of muscle damage with Gemfibrozil, which could result in kidney damage or failure, especially if you are also on statins. If you experience sudden muscle pain, weakness, or dark-colored urine, seek medical advice promptly.

• Contraindications: Do not use Gemfibrozil if you have liver or severe kidney issues, gallbladder problems, or if you are taking medications such as repaglinide, simvastatin (Zocor), dasabuvir, or Uptravi (selexipag). Consult your healthcare provider if any of these conditions apply to you.

This safety information is crucial for ensuring the safe use of Gemfibrozil. Always consult your healthcare provider for personalized guidance and in case of any adverse reactions.

When taking this medication, some people may experience common side effects such as indigestion, stomach pain, or diarrhea. These effects are typically mild and temporary. If they persist or worsen, it’s advisable to consult with a healthcare provider for guidance. Additionally, some individuals might experience nausea, vomiting, constipation, fatigue, headache, or a spinning sensation. Skin reactions like rashes may also occur. While these are generally manageable, it's important to discuss any concerning symptoms with a healthcare professional.

This medication might rarely lead to more serious issues, such as gallstones and liver problems, which can manifest as persistent nausea or vomiting, severe abdominal pain, yellowing of the eyes or skin, and dark urine. Muscle problems that could potentially progress to a serious condition called rhabdomyolysis are also rare. Symptoms like muscle pain, tenderness, weakness, fever, or unusual tiredness should be reported immediately. In rare instances, there could be signs of kidney problems, infections, easy bruising, bleeding, irregular heartbeat, or numbness in the limbs.

Although a severe allergic reaction is uncommon, it is crucial to seek medical attention if symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing occur. While this list covers a range of possible side effects, it may not be exhaustive. If you notice other unusual effects, reaching out to a healthcare provider is recommended for further advice and management.

Gemfibrozil (Lopid) can interact with various medications, potentially altering their effectiveness or increasing side effects. It is crucial to inform your healthcare provider about all medications and supplements you are taking, including prescription, over-the-counter, vitamins, and herbal products.

Some drugs should not be used with Gemfibrozil, such as Ciprofibrate, Dasabuvir, Elagolix, Repaglinide, Selexipag, and Simvastatin, as they can lead to significant interactions. In certain situations, avoiding these combinations may be necessary.

There are other medications, like Amiodarone, Atorvastatin, Colchicine, and Lovastatin, where using Gemfibrozil together is usually not recommended, but your doctor might adjust the dosages if both drugs are needed for your treatment.

Additionally, medications such as Warfarin, Glipizide, and Montelukast may increase the risk of side effects when taken with Gemfibrozil. Your doctor may modify how you use these medicines to ensure the best therapeutic outcome. Always consult your healthcare professional before making any changes to your medication regimen.