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When using this medication, it is essential to be aware of the potential risks and precautions. Below are important safety details and instructions. Please consult your healthcare provider if you have any questions or concerns.

• Liver Damage: Fenofibrate may cause severe liver damage, potentially leading to liver failure or even death. Liver damage can occur at any point during treatment but may resolve after stopping the medication. Regular blood tests are required before and during treatment to monitor liver health. If lab results are concerning or symptoms such as abdominal swelling, pain, nausea, vomiting, jaundice, changes in stool color, or confusion occur, discontinue use and seek medical attention immediately. This medication is not suitable for those with existing liver conditions.

• Muscle Damage (Myopathy and Rhabdomyolysis): There is an increased risk of muscle damage with fenofibrate, which can escalate to muscle breakdown (rhabdomyolysis) and affect other organs. The risk is higher for individuals taking medications like statins or with conditions such as diabetes. Consult your healthcare provider if you are on other medications that could contribute to muscle damage. Seek immediate medical help if you experience fever, sudden muscle pain, cramps, weakness, or dark urine. Higher risk groups include older adults, individuals with kidney failure, diabetes, or hypothyroidism.

• Kidney Effects: Some patients may experience elevated creatinine levels, suggesting potential kidney damage. It is unclear if fenofibrate harms kidneys, but monitoring through blood tests is advised, especially for those over 65 or with diabetes or kidney issues. Report any changes in urination or dark urine to your healthcare provider.

• Allergic Reactions: Fenofibrate can cause severe allergic reactions, including life-threatening anaphylaxis. Symptoms such as hives, swelling of lips or tongue, or breathing difficulties require immediate medical attention.

• Gallstones: This medication increases the risk of gallstones. It is not recommended for those with gallbladder issues. Report symptoms such as abdominal or back pain, nausea, or vomiting to your provider for evaluation.

• Pancreatitis: Rarely, fenofibrate may lead to pancreas inflammation (pancreatitis), potentially due to high triglyceride levels or other causes. Sudden abdominal pain, nausea, vomiting, or fluid retention may indicate pancreatitis and should be promptly reported to a healthcare provider.

• Blood Clots: There is a risk of blood clots forming in the lungs (pulmonary embolism) or legs (deep vein thrombosis). Symptoms like chest pain, difficulty breathing, leg swelling, or tender, warm skin necessitate urgent medical care.

Contraindications: Fenofibrate should not be used by individuals with severe kidney disease, those on dialysis, with liver disease, gallbladder disease, or nursing mothers. Consult your healthcare provider if any of these conditions apply.

When taking this medication, it's important to be aware of potential side effects, which can range from common to serious. Common side effects include liver damage, affecting about 8% of users, lung problems (6%), and stomach pain (5%). Additionally, some individuals may experience back pain, headache, stuffy nose, nausea, constipation, or a rash. These are generally mild but should be discussed with a healthcare provider if they persist or become bothersome.

More serious side effects are rare but require immediate medical attention. These include severe allergic reactions, which may present as sore throat, fever, fatigue, rash, hives, painful blisters, skin reddening or peeling, and swollen lymph nodes. Liver damage may manifest as swelling of the stomach, stomach pain, nausea, vomiting, yellowing of the skin or eyes, and confusion. Severe muscle problems, which can lead to a condition called rhabdomyolysis, are indicated by muscle pain, cramps, weakness, fever, unusual tiredness, and dark-colored urine. Additionally, blood clots in the lungs or legs can occur, with symptoms such as chest pain, difficulty breathing, swelling or warmth in the legs, and tender leg muscles.

Although a very serious allergic reaction is rare, symptoms such as rash, itching or swelling of the face, tongue, or throat, severe dizziness, and trouble breathing warrant immediate medical help. This summary does not include all possible side effects. If you notice any other unusual symptoms, contact your healthcare provider.

Fenofibrate may interact with various medications, so it's important to inform your doctor and pharmacist about all the medications and supplements you are taking, whether they are prescription, over-the-counter, vitamins, or herbal products. Here are some key interactions to be aware of:

1. Blood Thinners: Fenofibrate can interact with blood thinners, such as warfarin, increasing the risk of bleeding. If these medications are used together, your doctor may need to adjust the dose and monitor your blood work closely.

2. Similar Medications: Avoid using fenofibrate alongside medications containing fenofibric acid, as they are very similar and can lead to an increased risk of side effects.

3. Ciprofibrate: It is not recommended to use fenofibrate with ciprofibrate. Your doctor may choose alternative treatments in such cases.

4. Statins and Other Anticoagulants: Combining fenofibrate with other medications like acenocoumarol, anisindione, atorvastatin, and other statins can increase the risk of side effects. If prescribed together, your doctor may adjust dosages or monitor you more closely.

5. Other Medications: Using fenofibrate with colestipol, cyclosporine, ezetimibe, or rosiglitazone may raise the likelihood of certain side effects, but these combinations might be necessary for your treatment. Your healthcare provider will decide the best course of action and may adjust dosages accordingly.

Always consult your healthcare provider before making any changes to your medication regimen to ensure safe and effective use.