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During the initial days of treatment, you might experience nausea, abdominal pain, diarrhea, or headaches. It's also possible to feel dizzy or tired. These side effects are usually mild and tend to resolve on their own. However, if they persist or worsen, it's important to consult your healthcare provider.

While the medication is generally well-tolerated, be aware of more serious side effects. Contact your doctor immediately if you experience a fast or irregular heartbeat. In rare instances, you may encounter very serious side effects. It is crucial to stop taking prucalopride and seek medical attention if you have severe abdominal pain that doesn't subside, bloody diarrhea, rectal bleeding, or any mental or mood changes, such as depression or thoughts of self-harm.

Although allergic reactions to this medication are uncommon, they can be serious. Seek urgent medical help if you notice symptoms like a rash, itching or swelling, especially on the face, tongue, or throat, severe dizziness, or difficulty breathing. Always inform your healthcare provider about any other side effects you experience.