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This information highlights key safety precautions for using this medication. It is important to be aware of these risks and discuss any concerns with your healthcare provider.

• Risk of Diarrhea from Clostridioides difficile Infection: The use of antibiotics, such as fosfomycin (Monurol), may increase your likelihood of developing an infection with the bacteria Clostridioides difficile (C. diff). This infection can lead to diarrhea, which in severe cases, can be life-threatening. Antibiotics can disrupt the balance of normal bacteria in your stomach and intestines, allowing C. diff to multiply excessively and cause infection.

Please note that there are no specific contraindications listed for this medication. Always consult your healthcare provider for personalized advice.

Common side effects:

• Diarrhea
• Nausea
• Headache
• Vaginal discomfort
• Dizziness
• Upset stomach

Serious side effects:

• Vision changes
• Unusual weakness
• Severe intestinal condition caused by C. difficile
• Persistent diarrhea
• Abdominal pain or cramping
• Blood or mucus in the stool
• Allergic reaction (rash, itching or swelling of face, tongue, or throat, severe dizziness, difficulty breathing)

When taking fosfomycin, it's important to be aware of potential interactions with other medications and certain health conditions. Fosfomycin can interact with various drugs, including vaccines like BCG, cholera, and typhoid vaccines, as well as medications such as Metoclopramide, Digoxin, and certain estrogens. These interactions can range from major to minor in significance. For example, combining fosfomycin with live vaccines may reduce the effectiveness of the vaccines, while taking it with metoclopramide can decrease the absorption of fosfomycin, potentially making it less effective.

Additionally, fosfomycin may interact with certain health conditions. Patients with a history of colitis should use fosfomycin cautiously, as it can increase the risk of Clostridioides difficile-associated diarrhea, a potentially serious condition. For individuals undergoing hemodialysis, fosfomycin is removed from the body during the dialysis process, so it's recommended to administer the medication after dialysis sessions to ensure its effectiveness. Those with renal dysfunction should also be cautious, as impaired kidney function can lead to decreased excretion of fosfomycin, resulting in prolonged side effects.

It's crucial to inform your healthcare provider about all medications you're currently taking, including over-the-counter drugs and supplements, as well as any existing health conditions. This information will help your provider determine if fosfomycin is appropriate for you and how to manage any potential interactions.