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Nabumetone, a nonsteroidal anti-inflammatory drug (NSAID), comes with several important safety considerations and warnings. It is crucial to be aware of the potential risks associated with its use and to consult with your healthcare provider if you have any concerns. Below are key points to consider:

• Increased Risk of Heart Attack or Stroke: Prolonged use of nabumetone may elevate the likelihood of experiencing a heart attack or stroke, particularly in individuals with a history of heart disease or those undergoing heart bypass surgery (CABG). The risk is heightened in older adults and those with risk factors like smoking, high blood pressure, or diabetes. It is advisable to use the medication for the shortest duration necessary and consult with your healthcare provider for alternative treatments if you are scheduled for heart surgery.

• Stomach and Intestinal Bleeding: Nabumetone may cause serious bleeding from the stomach or intestines, potentially without warning symptoms. This risk is increased in older adults and those with a history of gastrointestinal issues. Immediate medical attention should be sought if you experience persistent stomach pain, bloody or black stools, or vomit resembling coffee grounds.

• High Blood Pressure: The medication can raise blood pressure, particularly in individuals with a history of hypertension. Regular monitoring of blood pressure is recommended.

• Heart Failure: Nabumetone may exacerbate heart failure symptoms, including fluid retention, which can lead to heart attacks and hospitalizations. It is essential to discuss the risks and benefits with your provider if you have heart failure, and monitor for any worsening symptoms.

• Kidney and Liver Concerns: The drug may impair kidney function or cause liver problems. Notify your healthcare provider if you experience symptoms like irregular heartbeat, shortness of breath, or changes in urine output. Blood tests may be required to monitor kidney and liver health.

• Allergic Reactions: Those with a history of allergic reactions to aspirin or other NSAIDs should exercise caution. Seek immediate medical help if you develop hives, breathing difficulties, or swelling after taking nabumetone.

• Serious Skin Reactions: Nabumetone can cause severe skin reactions, including rashes and blistering. Discontinue use and consult your provider if such symptoms occur.

• Pregnancy Risks: The drug is not recommended during pregnancy, especially in the third trimester, due to potential harm to the unborn child. Discuss safer alternatives with your healthcare provider if you are or may become pregnant.

• Risk of Anemia: The medication may increase the risk of bleeding, potentially leading to anemia. Inform your provider if you experience symptoms like fatigue, pale skin, or dizziness. Regular blood tests may be necessary to monitor red blood cell levels.

For all the above concerns, it is important to have an ongoing conversation with your healthcare provider to weigh the risks and benefits of nabumetone in your specific situation.

Common side effects:

• upset stomach
• nausea
• vomiting
• constipation
• diarrhea
• gas
• dizziness
• drowsiness
• headaches

Less common but important to monitor:

• increase in blood pressure

Serious side effects:

• changes in hearing
• mental or mood alterations
• difficulty swallowing
• changes in urine output
• swelling in the ankles or feet
• unusual tiredness
• sudden weight gain
• severe liver disease
• persistent nausea or vomiting
• dark urine
• yellowing of the eyes or skin
• gastrointestinal bleeding
• black or tarry stools
• severe stomach pain
• allergic reactions
• fever
• swollen lymph nodes
• rash
• trouble breathing
• heart attack
• stroke
• serious skin reactions
• chest pain
• shortness of breath
• slurred speech
• skin blisters

Interactions with high risk of serious adverse effects and should be avoided:

• Ketorolac

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Aspirin
• Clopidogrel
• Enoxaparin
• Warfarin
• ACE inhibitors (such as Captopril, Lisinopril)
• Angiotensin II receptor blockers (such as Losartan, Valsartan)
• Lithium
• Methotrexate
• Diuretics (such as Furosemide)

Interactions with low risk that usually do not require a change in therapy:

• Celecoxib
• Ibuprofen
• Ketorolac