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This medication comes with important safety information detailing potential risks and necessary precautions. It is crucial to review these warnings and consult your healthcare provider if you have any concerns.

• Diarrhea: Diarrhea is a common side effect of Nerlynx (neratinib), usually occurring within the first month of treatment and lasting less than a week. Although rare, severe diarrhea may lead to dehydration, low blood pressure, and kidney damage. To address this, your healthcare provider will likely recommend taking an antidiarrheal medication like loperamide (Imodium A-D) alongside Nerlynx. Inform your provider immediately if diarrhea occurs, as they may need to adjust your treatment plan, which could involve changing the dose or discontinuing Nerlynx.

• Liver Damage: Nerlynx (neratinib) has the potential to cause liver damage. Your healthcare provider will monitor your liver function with regular lab tests during treatment. Notify your provider if you experience symptoms such as yellowing of the skin or eyes, dark urine, or pain in the upper right abdomen. Treatment adjustments, including dose reduction or discontinuation, may be necessary based on your liver health.

• Risk to Unborn Baby: This medication may harm an unborn baby. For females who can conceive, your healthcare provider will confirm that you are not pregnant before beginning treatment. It is essential to use effective birth control during treatment and for at least one month after the final dose. Males taking Nerlynx (neratinib) should also use birth control if their partner can become pregnant, continuing for at least three months post-treatment. Report any pregnancy immediately to your healthcare provider.

Please ensure you understand these warnings and discuss any concerns with your healthcare provider.

When taking this medication, you may experience a variety of side effects. Commonly, individuals report diarrhea, which affects up to 95% of users, along with nausea, vomiting, tiredness, and stomach pain. These are often mild and manageable, but if they persist or worsen, consult your healthcare provider. Other frequent side effects include a reduced appetite, constipation, weight loss, and a mild rash. Additionally, some may experience redness or pain in the mouth, dizziness, indigestion, dry skin, or nail changes.

For some, back or joint pain, muscle spasms, or symptoms resembling a urinary tract infection may occur. Upper respiratory tract infections and dry mouth have also been reported. While these effects are typically not severe, it's important to monitor them and discuss any concerns with your healthcare provider.

It's crucial to be aware of more serious side effects, which, although rare, require immediate medical attention. Severe diarrhea, liver damage—indicated by yellowing of the skin or eyes, dark urine, or upper stomach pain—are significant concerns. A very serious allergic reaction, while uncommon, may present with symptoms such as rash, swelling, or trouble breathing, and demands urgent medical care.

Monitoring your response to this medication and maintaining open communication with your healthcare provider can help manage any side effects effectively.