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The safety and warning information for Verzenio (abemaciclib) outlines important considerations for its use. It is essential to be aware of the potential risks and necessary precautions to manage them effectively. If you have any concerns, please consult your healthcare provider.

• Diarrhea: Diarrhea is a prevalent side effect when taking Verzenio (abemaciclib), potentially leading to dehydration or infection. Symptoms typically appear within the first few weeks of treatment and may persist for up to two weeks. At the onset of diarrhea, contact your healthcare team; an antidiarrheal such as loperamide (Imodium) may be recommended. Depending on severity, your dosage might need adjustment. Staying hydrated is crucial to mitigate fluid loss.

• Low White Blood Cell Counts: This medication can reduce your white blood cell count, increasing infection risk. Regular monitoring of blood counts is necessary, especially in the initial weeks of treatment. Monitor your temperature and inform your oncologist if you develop a fever or feel unwell, as a dose reduction or temporary cessation of the medication may be required.

• Lung Problems: Although rare, serious lung issues such as inflammation or interstitial lung disease can occur. Report any new or worsening breathing difficulties to your oncologist, who may adjust or discontinue your treatment if needed.

• Liver Problems: Verzenio (abemaciclib) can elevate liver enzyme levels, indicating potential liver irritation. This often occurs 3 to 6 months after starting treatment and may last up to two weeks. Regular blood tests will monitor enzyme levels. If elevated levels are detected, your oncologist might lower your dose or pause treatment. Be vigilant for symptoms like fatigue, loss of appetite, abdominal pain, or easy bruising, and notify your care team promptly.

• Blood Clots: Though infrequent, blood clots in the veins can develop, posing significant health risks. Seek immediate medical attention if you experience symptoms such as arm or leg pain and swelling, difficulty breathing, chest pain, or a rapid heartbeat.

• Harm to Unborn Baby: Animal studies suggest Verzenio (abemaciclib) may harm an unborn child. A pregnancy test is required before starting treatment if you can become pregnant. It is advised to use birth control during treatment and for at least three weeks after the last dose. Inform your oncologist immediately if you become pregnant during this period.

When taking this medication, it's important to be aware of potential side effects, which can range from mild to severe. Common side effects include nausea, vomiting, stomach pain, diarrhea, constipation, and headache. You might also experience changes in taste, loss of appetite, weight loss, tiredness, and temporary hair loss. These effects are generally mild and tend to resolve on their own, but consult your healthcare provider if they persist or worsen.

More serious side effects, though rare, require prompt medical attention. These include signs of liver damage such as persistent nausea, loss of appetite, yellowing of the skin or eyes, and dark urine. The medication may also lower blood cell counts, increasing the risk of infections, which could manifest as fever, chills, or a persistent sore throat. Blood clots are another serious concern, with symptoms like sudden chest pain, shortness of breath, swelling in the limbs, or severe headaches needing immediate attention.

Additionally, a serious allergic reaction to this medication is uncommon but can occur. Look out for symptoms like a rash, itching, swelling, severe dizziness, or difficulty breathing, and seek medical help immediately if these arise. While most people tolerate this medication well, it's crucial to be vigilant and contact your healthcare provider with any concerns or new symptoms.