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The following safety information outlines critical warnings and precautions associated with the use of Omeclamox Pak. Please read carefully and consult your healthcare provider if you have any questions or concerns.

• Risk to Unborn Babies: Clarithromycin, a component of Omeclamox Pak, has been associated with birth defects. Therefore, this medication is not recommended for pregnant individuals. Inform your healthcare provider if you are pregnant before starting the treatment.

• Severe Skin Reactions: There is a risk of developing severe skin conditions such as Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN) when taking Omeclamox Pak. Symptoms include fever, body aches, coughing, peeling skin, and painful blisters, particularly around sensitive areas like the eyes, mouth, throat, or genitals. Discontinue use and seek medical attention immediately if these symptoms occur.

• Drug Interactions: Omeclamox Pak may interfere with the metabolism of other drugs, potentially increasing their levels and the risk of serious side effects. Avoid using this medication with colchicine, Ergomar (ergotamine), dihydroergotamine, or pimozide, as it can lead to significant heart, liver, or kidney complications.

• Myasthenia Gravis: If you have a history of myasthenia gravis, using clarithromycin can exacerbate symptoms such as muscle weakness and breathing difficulties. Consult your healthcare provider if you have concerns regarding this risk.

• Severe Diarrhea: There is an increased risk of Clostridioides difficile-associated diarrhea (CDAD) while using Omeclamox Pak. If you have taken antibiotics in the past two months, inform your provider. Stop the medication and contact your healthcare provider if you experience bloody or watery stools, as these could indicate CDAD.

• Kidney Damage: Omeclamox Pak can cause kidney damage, often due to an allergy to proton pump inhibitors (PPIs) like omeprazole. Be alert to symptoms such as allergic reactions, changes in urination, nausea, fatigue, or loss of appetite, and seek medical advice immediately if they occur.

• Lupus Symptoms: PPIs, including omeprazole, may trigger or worsen lupus symptoms. If you develop a butterfly-shaped rash on your face, experience fatigue, joint pain or swelling, or skin lesions, discontinue use and consult your healthcare professional.

Contraindications: Do not use Omeclamox Pak if you have allergies to omeprazole, clarithromycin, amoxicillin, or related antibiotics (macrolides, penicillins, cephalosporins), or if you are taking Ergomar (ergotamine), dihydroergotamine, or pimozide. Always discuss your medical history and current medications with your healthcare provider before starting Omeclamox Pak.

When taking this medication, you may experience some mild side effects such as diarrhea, headache, nausea, vomiting, and a change in taste. These are generally not serious and often resolve on their own. However, if they persist or worsen, it is advisable to consult your healthcare provider. Other mild side effects include stomach pain, passing gas, acid reflux, upper respiratory infection, constipation, dizziness, rash, lack of energy, back pain, and cough.

On rare occasions, this medication may cause severe side effects that require immediate medical attention. These include symptoms of a serious allergic reaction such as trouble breathing, swelling of the face, tongue, arms, or legs, a severe rash or hives, chest pain, a racing heartbeat, dizziness, or fainting. Additionally, a severe skin reaction characterized by blistering, peeling, or painful sores, as well as fever, may occur.

A serious bacterial infection called C. difficile may also develop, leading to severe, frequent diarrhea, abdominal pain, and cramps. This condition can emerge during treatment or even weeks after its conclusion. Avoid using anti-diarrhea or opioid products if you suspect this condition, as they can exacerbate symptoms. Sudden kidney problems are another serious concern, with symptoms like blood in urine, changes in urination, nausea, fever, and confusion.

In rare cases, prolonged use of this medication might lead to oral thrush or a new yeast infection. Look out for symptoms such as white patches in the mouth or changes in vaginal discharge. If you notice any new or unusual symptoms, contact your healthcare provider promptly. While rare, these side effects are significant and should not be ignored.

Some medications that could interact with this drug include clopidogrel, mavacamten, methotrexate (especially at high doses), and St John's wort. Additionally, several drugs besides clarithromycin can impact heart rhythm by causing QT prolongation. These include amiodarone, disopyramide, dofetilide, pacritinib, pimozide, procainamide, quinidine, and sotalol, among others.

Certain medications can influence how clarithromycin is eliminated from the body, potentially affecting its effectiveness. Examples include rifamycins like rifabutin, as well as efavirenz, and nevirapine.

Clarithromycin can also slow down the elimination of other drugs, which might alter their effects. Affected medications include colchicine, digoxin, drugs used for erectile dysfunction or pulmonary hypertension (such as sildenafil and tadalafil), ergot alkaloids like ergotamine, flibanserin, some statins such as lovastatin and simvastatin, tamsulosin, tolvaptan, and ticagrelor.

Some products require stomach acid for proper absorption. Since omeprazole reduces stomach acid, it might impact the absorption and effectiveness of certain drugs, including atazanavir, erlotinib, levoketoconazole, nelfinavir, pazopanib, rilpivirine, sparsentan, and certain azole antifungals like itraconazole, ketoconazole, and posaconazole.

Avoid using medications containing esomeprazole while taking omeprazole due to their similarity. Additionally, this medication may interfere with specific laboratory tests, such as urine glucose tests, leading to potentially inaccurate results. It's important to inform lab personnel and all your healthcare providers that you are using this medication.