HomeConditionsDuodenal Ulcer

Duodenal Ulcer

Duodenal ulcers, also known as peptic ulcers, are open sores that form in the duodenum. Common causes include H. pylori infection, NSAID use, and excessive acid production. Symptoms include abdominal pain, nausea, and weight loss. Diagnosis involves medical history, physical examination, and endoscopy. Treatment includes medications to reduce acid production and promote healing.

Best medications for Duodenal Ulcer

Drug NameClassRouteStandard DosagePrice
PrevacidProton Pump InhibitorsOral15, 30 MGfrom$13.46
CarafateAluminum ComplexesOral1 GMfrom$54.67
NexIUMProton Pump InhibitorsOral2.5, 5, 20, 10, 40 MGfrom$10.16
Ibuprofen-FamotidineNSAID / Histamine-2 Antagonist CombinationsOral800-26.6 MGfrom$92.78
CimetidineHistamine-2 AntagonistsOral400, 200, 300, 5-2-17, 800, 10-5-40 MG/5MLfrom$404.78
PepcidHistamine-2 AntagonistsOral10-800-165, 20, 10, 40 MGfrom$8.39
Cimetidine HClHistamine-2 AntagonistsOral400, 300 MG/5MLfrom$404.78
ZegeridProton Pump InhibitorsOral20-1680, 20-1100, 40-1100, 40-1680 MGfrom$22.09
PriLOSECProton Pump InhibitorsOral2.5, 20, 10 MGfrom$16.67
AciphexProton Pump InhibitorsOral20 MGfrom$13.67


Duodenal ulcer, also known as peptic ulcer, is a chronic condition characterized by the formation of open sores or ulcers in the first part of the small intestine, called the duodenum. These ulcers develop when the protective lining of the duodenum is eroded, allowing stomach acid and digestive juices to irritate the sensitive tissues underneath. Duodenal ulcers are fairly common and can cause various symptoms ranging from mild discomfort to severe pain. In this article, we will explore the causes, symptoms, diagnosis, and treatment options for duodenal ulcers.

Causes of Duodenal Ulcers

Duodenal ulcers develop as a result of an imbalance between the factors that protect the lining of the duodenum and those that promote its erosion. The primary causes of duodenal ulcers include: 1. Helicobacter pylori infection: This bacterium is the most common cause of duodenal ulcers. It weakens the protective mucus layer of the duodenum, making it vulnerable to acid damage. 2. Nonsteroidal anti-inflammatory drugs (NSAIDs): Frequent and prolonged use of medications like aspirin, ibuprofen, and naproxen can increase the risk of duodenal ulcers by irritating the lining of the stomach and duodenum. 3. Excessive acid production: Certain medical conditions, such as Zollinger-Ellison syndrome, can lead to overproduction of stomach acid, which can cause duodenal ulcers.

Symptoms of Duodenal Ulcers

The signs and symptoms of duodenal ulcers may vary from person to person. Some common symptoms include: 1. Abdominal pain: The most prominent symptom of duodenal ulcers is a gnawing or burning pain in the middle or upper abdomen. This pain often occurs between meals and can be relieved by eating or taking antacid medications. 2. Nausea and vomiting: Some individuals with duodenal ulcers may experience feelings of nausea or may vomit blood, which indicates a more severe ulcer. 3. Loss of appetite and weight loss: Chronic duodenal ulcers can lead to a decrease in appetite, resulting in unintended weight loss. 4. Indigestion and bloating: Duodenal ulcers can cause symptoms commonly associated with indigestion, such as bloating, belching, and a feeling of fullness after meals.

Diagnosis of Duodenal Ulcers

To diagnose duodenal ulcers, a healthcare provider may perform the following: 1. Medical history and physical examination: The doctor will gather information about the patient's symptoms and medical history. They will also conduct a physical examination to check for signs of an ulcer. 2. Endoscopy: A thin, flexible tube with a light and camera on the end (endoscope) is inserted through the mouth and into the esophagus, stomach, and duodenum. This allows the doctor to visualize the ulcer and collect tissue samples for further analysis. 3. Imaging tests: In some cases, imaging tests like X-rays or CT scans may be ordered to determine the extent and location of the ulcer.

Treatment of Duodenal Ulcers

The treatment of duodenal ulcers aims to relieve symptoms, promote healing, and prevent complications. Common treatment options include: 1. Medications: Proton pump inhibitors (PPIs) and H2 receptor antagonists are commonly prescribed to reduce stomach acid production and promote healing. Antibiotics may also be prescribed to eradicate H. pylori infection if present. 2. Antacids and acid reducers: Over-the-counter antacids can provide temporary relief by neutralizing stomach acid