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The following safety and warning information is essential for anyone considering or currently using Zegerid (omeprazole / sodium bicarbonate). Please review these points and consult with your healthcare provider if you have any questions or concerns.

• Follow-up with Healthcare Provider: If Zegerid alleviates your stomach symptoms but they return, contact your healthcare provider. Recurring symptoms may indicate a more serious condition, such as stomach cancer, necessitating further medical evaluation.

• Kidney Damage: There is a risk of kidney damage associated with proton pump inhibitors (PPIs) like omeprazole. If you experience symptoms such as blood in the urine, altered urination frequency, nausea, fever, or confusion, discontinue use immediately and consult a healthcare professional.

• Severe Skin Reactions: Rare but serious skin reactions, including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), can occur. Seek immediate medical attention if you experience flu-like symptoms alongside skin rash, blisters, or peeling.

• High Sodium Content: Zegerid contains sodium, which may cause swelling and weight gain, particularly problematic for those on a low-sodium diet or with conditions such as heart failure or hypertension. Discuss any sodium intake concerns with your healthcare provider before starting this medication.

• Milk-Alkali Syndrome: Long-term use of Zegerid, especially when taken with calcium supplements or milk, may lead to milk-alkali syndrome, affecting kidney function. Symptoms include nausea, frequent urination, headache, or dizziness. Consult your provider if these occur.

• Severe Diarrhea: There is an increased risk for bacterial infections causing severe diarrhea. If you experience persistent watery diarrhea, fever, or stomach pain, seek medical advice promptly. Use the lowest effective dose for the shortest duration to minimize this risk.

• Bone Fractures: Long-term or high-dose use of Zegerid may increase the risk of bone fractures. Your provider may recommend vitamin D and calcium supplements. Discuss additional strategies for maintaining bone health with your healthcare provider.

• Lupus: PPIs like omeprazole can potentially cause or exacerbate lupus. Symptoms may vary, such as joint pain or rash. Use the lowest effective dose for the shortest time, and consult your provider about lupus symptoms. Symptoms should improve within 1-3 months after discontinuation.

• Drug Interactions: Zegerid can interact with various medications, vitamins, and herbal supplements, potentially affecting their efficacy or safety. Notably, it may reduce the effectiveness of warfarin and certain HIV medications while increasing methotrexate levels. Inform your healthcare provider of all substances you are taking.

• Low Vitamin B12 and Magnesium Levels: Extended use of Zegerid may result in reduced blood levels of magnesium or vitamin B12, particularly after prolonged periods. Monitor your health if using this medication long-term.

• Stomach Growths: Prolonged use may elevate the risk of developing small stomach growths. These typically show no symptoms, but it's advisable to keep treatment duration as short as possible.

• Contraindications: Do not use Zegerid if you are taking rilpivirine-containing medications or have an allergy to benzimidazoles. Consult your healthcare provider if these conditions apply to you.

In case of an overdose or any severe reaction, seek emergency medical assistance immediately. Always communicate openly with your healthcare provider about your treatment and any concerns.

When taking this medication, some individuals may experience mild side effects such as headache, stomach pain, diarrhea, nausea, gas, or vomiting. These are usually not a cause for concern, but if they persist or worsen, consulting a healthcare provider is advised. Other side effects like upper respiratory infections, dizziness, rash, constipation, and a lack of energy have also been reported, and seeking medical advice if they occur is recommended.

More serious side effects, though rare, need urgent medical attention. These include severe diarrhea with symptoms like watery stools, fever, and persistent stomach pain, as well as serious kidney problems indicated by blood in urine or changes in urination frequency. Additionally, a severe skin reaction may manifest as fever, rash, blisters, and other symptoms. It is crucial to seek immediate care if you experience signs of seriously low magnesium levels, such as an irregular heart rate, muscle cramps, tremors, or seizures.

While an allergic reaction to this drug is uncommon, symptoms like fever, swollen lymph nodes, rash, severe dizziness, or trouble breathing require prompt medical help. It's also important to be aware of the risk of vitamin B-12 deficiency if the medication is used daily for an extended period, marked by unusual weakness, a sore tongue, or numbness in the hands or feet. Always discuss any new or worsening symptoms with your healthcare provider for appropriate guidance.

Omeprazole combined with sodium bicarbonate, also known as Zegerid, can interact with a variety of medications and supplements. It is important to inform your healthcare provider about all medications and supplements you are taking, including those prescribed, over-the-counter, vitamins, and herbal products.

Interactions with Zegerid may affect the effectiveness or safety of certain drugs. For instance, it is advised not to use Zegerid with rilpivirine. If certain medications are necessary, such as clopidogrel, atazanavir, erlotinib, methotrexate (especially in high doses), memantine, nelfinavir, or St John's Wort, your doctor may need to adjust doses or monitor you closely for side effects.

Zegerid works by reducing stomach acid, which can impact the absorption of drugs that require acid to be absorbed effectively. This includes medications like atazanavir, erlotinib, certain antifungals (itraconazole, ketoconazole, posaconazole), and others.

Additionally, avoid using esomeprazole-containing products while on omeprazole, as they are very similar. Be aware that Zegerid may also interfere with some laboratory tests, potentially leading to inaccurate results. Always ensure that your healthcare professionals are aware that you are taking this medication.