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This medication carries important safety warnings and precautions that should be thoroughly reviewed. Please consult your healthcare provider if you have any concerns or questions.

• Use During Pregnancy and Postpartum: Limited research exists on the safety of bromocriptine (Parlodel) during pregnancy. Rare but serious conditions such as high blood pressure, heart attack, seizures, and stroke have been reported in individuals taking this medication postpartum.

• Drowsiness and Sudden Sleep Episodes: Bromocriptine (Parlodel) may cause sleepiness, particularly when used for Parkinson’s disease. There is a rare risk of falling asleep suddenly, even without prior drowsiness. Refrain from driving or engaging in activities that require full attention until you understand how this medication affects you. Notify your healthcare provider if you experience excessive daytime sleepiness or unexpected sleep episodes. This risk increases if you have a history of drowsiness, sleep disorders, or are taking other sedatives.

• Blood Pressure Changes: This medication may alter blood pressure, potentially causing low blood pressure when initiating treatment. Symptoms can include fatigue, dizziness, vision changes, or faintness. This risk is higher if you have uncontrolled blood pressure, are on medications affecting blood pressure, or have recently given birth.

• Impulsive Behavior: Bromocriptine (Parlodel) may lead to reduced impulse control, resulting in strong urges such as gambling, spending excessively, or binge eating. If these behaviors negatively affect your life, contact your healthcare provider. Adjusting or discontinuing the dose may be necessary.

• Fluid Accumulation Around Heart or Lungs: Rare cases of lung and heart issues have been reported. Seek immediate medical attention if you experience shortness of breath, chest pain, cough, or irregular heartbeat. The risk increases with high doses or prolonged use of bromocriptine (Parlodel).

• Blood Flow Issues: Some individuals taking bromocriptine (Parlodel) for acromegaly may develop digital vasospasm, leading to decreased blood flow to fingers or toes, often triggered by cold. Report any painful, discolored fingers or toes to your healthcare provider. Dose adjustment and keeping extremities warm may help.

Contraindications

This medication should not be used in certain conditions due to serious health risks. Consult your healthcare provider before use if any of the following apply:

• Uncontrolled high blood pressure
• Allergy to ergot alkaloids
• Postpartum period for females with a history of heart disease

Please ensure you follow these guidelines and seek medical advice if you have any concerns.

When taking this medication, you may experience common side effects such as nausea, headache, dizziness, constipation, tiredness, lightheadedness, and vomiting. These effects are generally mild and should be monitored, especially if they persist or worsen. Other possible side effects include stomach cramps, an upset stomach, diarrhea, dry mouth, loss of appetite, stuffy nose, drowsiness, weakness, and trouble sleeping. It's important to remain calm, as many users do not experience serious issues.

However, there are more severe side effects that necessitate immediate medical attention. These include dangerously high blood pressure, characterized by chest pain, persistent headache, irregular heartbeat, vision problems, difficulty breathing, nosebleed, or blood in your urine. Additionally, painful or discolored fingers or toes and severe allergic reactions such as rash, itching, swelling, severe dizziness, or trouble breathing require urgent care.

Some individuals have reported falling asleep suddenly during daily activities, which can occur without prior drowsiness. This risk is increased by alcohol or other sedatives. Monitor your blood pressure, especially when starting or adjusting doses, as sudden changes might cause dizziness or fainting. If you experience serious symptoms like persistent runny nose, back pain, limb swelling, signs of kidney issues, severe stomach pain, black or bloody stools, coffee-ground vomit, cold extremities, tingling or numbness, mental changes, unusual strong urges, or irregular heartbeat, contact a healthcare provider promptly. Always prioritize your safety and seek help when needed.

Bromocriptine (Parlodel) can have interactions with a variety of medications, so it is important to inform your doctor and pharmacist about all other medications and supplements you are taking, whether they are prescribed or over-the-counter.

Certain drugs should not be used with bromocriptine, as they may lead to serious interactions. These include medications like Eletriptan, Frovatriptan, letermovir, Naratriptan, Rizatriptan, sulpiride, Sumatriptan, and Zolmitriptan. In these instances, your doctor may advise against using bromocriptine or adjust your other treatments.

Other medications may typically not be recommended for use with bromocriptine but might be necessary in some cases. Examples are abametapir, Almotriptan, Amoxapine, boceprevir, ceritinib, Clarithromycin, Clomipramine, cobicistat, conivaptan, Dihydroergotamine, fosnetupitant, Haloperidol, idelalisib, indinavir, isometheptene, Itraconazole, Ketoconazole, lopinavir, Metoclopramide, Nefazodone, nelfinavir, netupitant, phenylpropanolamine, Posaconazole, propatyl nitrate, Ritonavir, saquinavir, telaprevir, telithromycin, thioctic acid, and Voriconazole. If prescribed together, your doctor may need to adjust dosages or how frequently you take these medications.

Additionally, using bromocriptine with certain drugs like bromperidol, Cyclosporine, kava, and Thioridazine may increase the risk of side effects. In such cases, your healthcare provider might modify the dose or schedule of your treatments.

Furthermore, some drugs can influence how bromocriptine is eliminated from your body, potentially altering its effectiveness. These include azole antifungals (such as itraconazole, ketoconazole), macrolide antibiotics (such as clarithromycin, Erythromycin), and HIV protease inhibitors (like lopinavir and ritonavir).

If you are taking other substances that cause drowsiness, such as alcohol, marijuana, antihistamines, medications for sleep or anxiety, muscle relaxants, or opioid pain relievers, you should inform your healthcare provider. Always check labels on medications for ingredients that may cause drowsiness and consult your pharmacist for safe usage.

By keeping your healthcare team informed, you can help prevent potential interactions and ensure your treatment is both safe and effective.