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The following safety and warning information is crucial for anyone considering or currently using bromocriptine (Parlodel). Please read carefully and discuss any concerns with your healthcare provider.

• Use During Pregnancy and Postpartum: There is limited data on the safety of bromocriptine during pregnancy. Rare cases of severe high blood pressure, heart attacks, seizures, and stroke have been reported in postpartum individuals using this medication.

• Drowsiness and Sudden Sleep: Bromocriptine may cause drowsiness, especially in Parkinson's disease patients, and can occasionally lead to unexpected sleep episodes. Refrain from driving or engaging in activities requiring full attention until you understand how this medication affects you. Extra caution is advised for those with a history of sleep issues or who are taking other sedatives. Report excessive daytime sleepiness or sleep during activities to your healthcare provider.

• Blood Pressure Changes: This medication can cause blood pressure fluctuations. Initially, you might experience low blood pressure, presenting as fatigue, dizziness, vision changes, or faintness. This is particularly a risk for those with uncontrolled blood pressure, those taking blood pressure-altering medications, or recent postpartum individuals.

• Impulsive Behavior: Some users may experience reduced impulse control, leading to urges such as excessive gambling, spending, or eating. If these impulses adversely affect your life, consult your provider about adjusting your dosage or discontinuing use.

• Heart or Lung Fluid Accumulation: Rarely, bromocriptine users may develop unexplained heart or lung issues, indicated by symptoms such as shortness of breath, chest pain, coughing, or irregular heartbeat. Immediate medical attention is necessary if these occur. Risks are higher with long-term or high-dose use.

• Blood Flow Disorders: Users, especially those treating acromegaly, might develop digital vasospasm, causing reduced blood flow to fingers or toes, often triggered by cold. If you experience painful, discolored digits, consult your provider. Lowering the dose and keeping extremities warm may help.

Contraindications: Bromocriptine should not be used in individuals with:

• Uncontrolled high blood pressure
• A known allergy to ergot alkaloids
• A history of heart disease during the postpartum period

Always consult your healthcare provider before starting bromocriptine if any of these conditions apply to you.

Common side effects:

• nausea
• headache
• dizziness
• constipation
• tiredness
• vomiting
• lightheadedness
• stomach cramps
• upset stomach
• dry mouth
• loss of appetite
• stuffy nose
• drowsiness
• weakness
• trouble sleeping

Less common but important to monitor:

• persistent runny nose
• back pain
• swelling in the legs or feet
• severe stomach pain
• black or bloody stools
• vomit resembling coffee grounds
• signs of kidney issues
• unusual urges
• mental changes

Serious side effects:

• severe headaches
• seizures
• trouble speaking
• weakness on one side of the body
• vision changes
• chest pain
• breathing difficulties
• allergic reactions, such as a rash or swelling

Interactions with high risk of serious adverse effects and should be avoided:

• Eletriptan
• Frovatriptan
• Letermovir
• Naratriptan
• Rizatriptan
• Sulpiride
• Sumatriptan
• Zolmitriptan

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

• Abametapir
• Almotriptan
• Amoxapine
• Boceprevir
• Ceritinib
• Clarithromycin
• Clomipramine
• Cobicistat
• Conivaptan
• Dihydroergotamine
• Fosnetupitant
• Haloperidol
• Idelalisib
• Indinavir
• Isometheptene
• Itraconazole
• Ketoconazole
• Lopinavir
• Metoclopramide
• Nefazodone
• Nelfinavir
• Netupitant
• Phenylpropanolamine
• Posaconazole
• Propatyl Nitrate
• Ritonavir
• Saquinavir
• Telaprevir
• Telithromycin
• Thioctic Acid
• Voriconazole

Interactions with low risk that usually do not require a change in therapy:

• Bromperidol
• Cyclosporine
• Kava
• Thioridazine