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This medication, which combines oxycodone and acetaminophen, carries several important safety warnings and precautions that you should be aware of before use. It is crucial to follow your healthcare provider's instructions closely to minimize risks.

• Risk of Abuse and Addiction: Oxycodone/acetaminophen is a controlled substance with a high potential for addiction and misuse, which can lead to overdose and death. Always take the medication exactly as prescribed, and never adjust the dose without consulting your healthcare provider. Individuals with a history of substance use disorders or mental health problems may be at greater risk.

• Breathing Problems: This medication can cause severe, potentially fatal respiratory depression, especially when starting treatment or increasing the dose. Do not combine it with alcohol or other drugs that depress the central nervous system, such as benzodiazepines or muscle relaxants. Carry naloxone if prescribed, and ensure your family knows how to use it and recognize signs of an overdose, such as slow or shallow breathing and bluish-colored lips or skin.

• Overdose Risks: Taking more than the prescribed dose can lead to an opioid overdose, characterized by symptoms like extreme drowsiness, slow heartbeat, and unresponsiveness. Always have naloxone on hand and seek emergency help if an overdose is suspected.

• Liver Damage: Acetaminophen can cause significant liver damage if taken in excess. Adults should not exceed 4 grams per day. Avoid alcohol and check all medications for acetaminophen content to prevent overdose.

• Special Populations: Pregnant women should use oxycodone/acetaminophen only when necessary, as it may harm the unborn child or lead to neonatal withdrawal syndrome. Consult your doctor if you are pregnant or planning to become pregnant.

• Drug Interactions: This medication can interact with many drugs, potentially increasing the risk of side effects. Inform your healthcare provider about all medications you are taking, especially erythromycin, ketoconazole, and ritonavir.

• Allergic Reactions: Severe allergic reactions, including anaphylaxis, can occur. Discontinue use and seek immediate medical attention if you experience symptoms such as swelling, rash, or difficulty breathing.

• Withdrawal Symptoms: Long-term use can lead to physical dependence. Do not stop taking the medication abruptly without consulting your healthcare provider to avoid withdrawal symptoms like anxiety and restlessness.

• Other Risks: Be cautious of side effects such as extreme sleepiness and concentration difficulties. Avoid activities requiring full alertness, like driving, until you understand how the medication affects you. Additionally, be aware that this medication can cause low blood pressure, seizures, and low adrenal hormone levels in certain individuals.

Always store this medication securely to prevent misuse and keep it out of reach of children and pets. If accidental ingestion occurs, seek medical attention immediately.

When taking this medication, some individuals might experience common side effects such as nausea, vomiting, constipation, dizziness, lightheadedness, drowsiness, and itching. These are generally mild and may subside over time. To manage constipation, consider a diet rich in fiber, stay hydrated, and engage in regular exercise. Dizziness and lightheadedness can be minimized by rising slowly from sitting or lying positions.

There are other side effects that some users may encounter, including headaches, sweating, heartburn, bloating, changes in taste, stomach pain, muscle pain, and variations in blood pressure or heartbeat. If these occur, especially in a severe form, it's important to contact a healthcare provider for advice.

On rare occasions, more serious side effects may develop, which necessitate immediate medical attention. These include dangerously slow or shallow breathing, symptoms of an overdose like extreme sleepiness and slow heartbeat, and signs of an allergic reaction such as rash, hives, or difficulty breathing. Additionally, symptoms of opioid withdrawal or serious skin reactions should be addressed promptly.

While a very serious allergic reaction is rare, seek help without delay if you notice swelling, severe dizziness, or trouble breathing. If you experience any other side effects not mentioned, it is advisable to consult your healthcare provider. Remember, though these side effects can occur, many people use this medication without experiencing severe complications.

Percocet, which contains oxycodone and acetaminophen, can interact with various other medications, potentially leading to serious side effects. It's crucial to inform your doctor and pharmacist about all medications and supplements you are taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements.

Certain medications should not be combined with Percocet, such as nalmefene, naltrexone, and safinamide, as they may counteract its effects. Additionally, combining Percocet with drugs like mixed opioid agonist/antagonists (e.g., butorphanol, nalbuphine, pentazocine), or with samidorphan, is usually not recommended. If these are used together, your doctor might adjust the dosage or frequency of one or both medications.

Percocet may also enhance side effects when taken with substances that cause drowsiness or breathing problems, such as other opioid pain relievers (e.g., codeine, hydrocodone), alcohol, cannabis, sedatives for sleep or anxiety (e.g., alprazolam, lorazepam), muscle relaxants (e.g., carisoprodol, cyclobenzaprine), and antihistamines (e.g., cetirizine, diphenhydramine). Always check medication labels for ingredients that might induce drowsiness and consult your pharmacist if you have questions about safe use.

Drugs that affect how Percocet is processed in the body, like azole antifungals (e.g., ketoconazole), macrolide antibiotics (e.g., erythromycin), or certain seizure medications (e.g., carbamazepine, phenytoin), may alter its effectiveness. It's important to discuss all these potential interactions with your healthcare provider to ensure safe and effective treatment.