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The safety information for this medication outlines important risks and precautions that should be taken seriously. It is crucial to review these warnings carefully and consult your healthcare provider with any concerns.

• Pregnancy Risks: This medication can lead to serious and potentially fatal harm to an unborn baby. Avoid using this medication during pregnancy. If you become pregnant or are planning to conceive, inform your doctor immediately to discuss safer alternatives for managing your condition.

• Angioedema: This medication may cause angioedema, a rare but serious condition characterized by swelling of the face, throat, or tongue, which can obstruct breathing. This side effect can occur at any time during treatment. Those who are Black, female, or older adults are at greater risk. Immediate medical attention is necessary if swelling or difficulty breathing occurs.

• Low Blood Pressure: The medication may cause a significant drop in blood pressure, leading to dizziness, tiredness, or lightheadedness, especially at the start of treatment or when the dose is increased. Ensure proper hydration, and if you experience severe dizziness or fainting, contact your healthcare provider promptly.

• Kidney Concerns: Though beneficial for kidneys in many cases, this medication can exacerbate kidney issues, particularly in individuals with pre-existing conditions like renal artery stenosis or severe heart failure. Regular monitoring of kidney function is recommended, and reduced urination should be reported to your provider.

• High Potassium Levels: This medication can elevate potassium levels in the body, posing risks such as abnormal heart rhythms. Inform your healthcare provider of your full medical history and concurrent medications. Symptoms like nausea, muscle weakness, or irregular heartbeats should be reported immediately.

• Liver Issues: Rarely, this medication can lead to liver complications, including liver failure. Those with a history of liver problems or heavy alcohol use should be monitored closely. Symptoms such as fatigue, abdominal pain, or yellowing of the skin should prompt immediate consultation with your doctor.

Contraindications:

• History of angioedema.
• Concurrent use with aliskiren (Tekturna) in patients with high blood sugar.
• Use within 36 hours of neprilysin inhibitors like Entresto (sacubitril/valsartan).

In the event of an overdose, seek emergency medical attention immediately. Always discuss potential interactions with other medications or substances with your healthcare provider before starting treatment.

When taking this medication, some individuals may experience common side effects such as dizziness, low blood pressure, elevated creatinine levels, and headaches. These effects are generally mild and should subside as your body adjusts. However, if they persist or worsen, it's advisable to consult your healthcare provider. A dry cough and the sensation of feeling faint have also been reported by some users.

There are rare but serious side effects associated with this medication that require immediate medical attention. These include angioedema, characterized by swelling of the face, arms, legs, lips, tongue, or throat, which can lead to breathing difficulties. Dangerously low blood pressure may manifest as dizziness, lightheadedness, pale skin, or fainting. Serious kidney issues might present as reduced urination, swelling in the extremities, or unexpected weight gain. Additionally, high blood potassium levels can cause nausea, muscle weakness, or an irregular heartbeat.

Liver problems, though rare, are severe and can be indicated by symptoms such as persistent nausea or vomiting, abdominal pain, loss of appetite, yellowing of the skin or eyes, and dark urine. A serious allergic reaction, while uncommon, would involve symptoms like severe rash, itching, or swelling, especially in the facial area, as well as trouble breathing. If any of these serious side effects occur, seek urgent medical help promptly.

Lisinopril, also known as Zestril, may interact with various medications, so it's important to inform your doctor and pharmacist about all the drugs, vitamins, and supplements you are using, whether they are prescription or over-the-counter.

Certain drugs, like Aliskiren and Sacubitril, are not recommended to be taken with Lisinopril due to potential interactions. Your doctor might advise against using these medications together or may alter your treatment plan.

In some instances, using Lisinopril with specific drugs may not be ideal but might be necessary. In such cases, your doctor could adjust the dosage or frequency of either medication. These drugs include Everolimus, Sirolimus, Lithium, and others that may increase potassium levels in the blood, such as ARBs (e.g., Losartan, Valsartan) and birth control pills containing drospirenone.

Additionally, combining Lisinopril with non-steroidal anti-inflammatory drugs (NSAIDs) like Ibuprofen or Naproxen, and certain other medications, might increase the risk of side effects. However, your doctor may determine that the benefits of using both medications outweigh the risks and adjust the treatment accordingly.

Lastly, if you are undergoing desensitization injections for bee or wasp sting allergies, it's crucial to inform all your healthcare providers that you are taking Lisinopril, as a severe reaction could occur.