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This medication involves important safety considerations that must be understood before use. If you have any questions or concerns, please discuss them with your healthcare provider.

• Heart Concerns: Although nitroglycerin (Rectiv) is applied in the anal region, it can be absorbed into the bloodstream, potentially causing low blood pressure and affecting heart performance. Individuals with a history of heart problems, dehydration, or naturally low blood pressure should consult their healthcare provider to evaluate these risks.

• Headache: Initial use of nitroglycerin (Rectiv) may result in headaches, which can be severe but typically improve with continued use. Avoid exceeding the prescribed dose, as it may intensify headaches. Using a pain reliever like acetaminophen (Tylenol) can help manage this side effect. If headaches persist or worsen, seek advice from your healthcare provider for alternative treatments.

Contraindications: This medication should be avoided under certain conditions due to potential health risks. Consult your healthcare provider if any of the following apply:

• Concurrent use of PDE5 inhibitors
• Severe anemia
• Elevated intracranial pressure
• Allergy to nitrates or nitrites

It is essential to follow these guidelines to ensure safe and effective use of the medication.

When using this medication, some individuals may experience common side effects such as headaches, which are reported by 64% of users. These headaches are usually short-lived after each dose and often diminish with continued use. Additionally, dizziness and lightheadedness, resulting from a drop in blood pressure, may occur in about 5% of users. To minimize these effects, it is advisable to rise slowly from sitting or lying positions.

Although these side effects are generally mild, it is important to consult your healthcare provider if they persist or worsen. While serious side effects are rare, a severe allergic reaction could occur. Symptoms of such a reaction include rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, and difficulty breathing. Immediate medical attention is crucial if any of these symptoms are experienced.

This summary covers possible side effects, but if you notice any effects not listed, reaching out to your healthcare provider is recommended for further guidance.

Nitroglycerin (Rectiv) may interact with several medications, and it is important to inform your doctor and pharmacist about all the medications or supplements you are taking, whether they are prescribed, over-the-counter, vitamins, or herbal supplements. Some interactions to be aware of include:

• Not Recommended Combinations: Nitroglycerin should not be used with erectile dysfunction drugs such as Avanafil, Sildenafil, Tadalafil, and Vardenafil, as well as medications like Riociguat. These combinations can lead to significant interactions, and your doctor may choose alternative treatments.

• Cautionary Combinations: While not usually recommended, using Nitroglycerin with Alteplase, Recombinant may be necessary in certain situations. If prescribed together, your doctor might adjust dosages or usage frequency.

• Potential Side Effects: Combining Nitroglycerin with Acetylcysteine, Apomorphine, Aspirin, Dihydroergotamine, or Pancuronium may increase the risk of certain side effects. Your treatment plan may involve both medications, and your doctor will manage dosages accordingly.

Always follow your healthcare provider’s guidance when it comes to combining medications.