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This document outlines vital safety information and warnings related to the use of Ranolazine (Ranexa). It is crucial to fully understand these details and discuss any concerns with your healthcare provider.

• Abnormal Heart Rhythm: Ranolazine (Ranexa) may disturb the regular rhythm of your heart, potentially causing it to beat abnormally. Regular monitoring through electrocardiograms (EKGs) may be required. Do not exceed the prescribed dosage. If you or a family member have a history of "long QT" syndrome, inform your doctor. Additionally, disclose all medications you are taking, as combining them with ranolazine could increase the risk of heart rhythm issues. Seek immediate medical attention if you experience abnormal heart rate, chest pain, dizziness, difficulty breathing, or fainting.

  • Risk Factors: Family or personal history of "long QT" syndrome, concurrent use of drugs that prolong the QT interval.

• Kidney Problems: This medication may impair kidney function, particularly in individuals with pre-existing kidney conditions. Your healthcare provider may perform regular blood tests to monitor kidney health. If you notice changes in urination, blood or foam in urine, fatigue, dry or itchy skin, muscle cramps, or decreased appetite, contact your provider promptly as these could indicate kidney issues.

  • Risk Factors: History of severe kidney problems.

• Drug Interactions: Ranolazine (Ranexa) can interact with various medications, potentially leading to increased levels of ranolazine or other drugs in the body and a heightened risk of side effects.

  • Risk Factors: Use of multiple medications.

Contraindications: Ranolazine (Ranexa) should not be used under the following conditions due to serious health risks. Consult your healthcare provider if any of these apply to you:

• Use of certain medications that interact with ranolazine.
• Presence of liver cirrhosis.

Always inform your healthcare provider about your complete medical history and current medications to ensure safe use of Ranolazine (Ranexa).

When taking this medication, some individuals may experience common side effects like dizziness, headache, nausea, tiredness, and constipation. These effects are usually mild and manageable, but if they persist or worsen, it is important to consult with a healthcare provider. To help minimize dizziness and lightheadedness, try standing up slowly from sitting or lying down.

There are other side effects that have been reported by some users, including dry mouth, stomach pain, vomiting, and swelling in the arms or legs due to fluid retention. If you notice these symptoms, especially if they become severe, contact your healthcare provider.

On rare occasions, more serious side effects can occur and require immediate medical attention. These include abnormal heart rhythms, characterized by a racing or irregular heartbeat, severe dizziness, fainting, or difficulty breathing. Additionally, signs of serious kidney problems, such as changes in urination, blood or foam in the urine, muscle cramps, and swelling in the feet or ankles, should be addressed immediately. Lastly, while a serious allergic reaction is rare, symptoms like rash, swelling, or difficulty breathing necessitate urgent medical care. Always keep an open line of communication with your healthcare provider regarding any side effects you experience.

Ranolazine, also known as Ranexa, can interact with a variety of medications and supplements. It is important to inform your doctor and pharmacist about all the medications you are taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements. Some drugs can influence how ranolazine is processed in your body, potentially altering its effectiveness.

Certain medications should not be taken with ranolazine, as they can significantly affect its removal from your body. These include azole antifungals (like itraconazole and ketoconazole), clarithromycin, cobicistat, nefazodone, HIV protease inhibitors (such as nelfinavir), and rifamycins (like rifabutin and rifampin). Additionally, drugs used for seizures, such as carbamazepine, phenobarbital, and phenytoin, as well as herbal supplements like St. John's wort, can also impact ranolazine's effectiveness.

There are other medications that are generally not recommended to be taken with ranolazine but might be necessary in some cases. If both medications are prescribed together, your healthcare provider might adjust the dosages or frequency. These medications include a wide range of drugs, such as amiodarone, ciprofloxacin, diltiazem, and verapamil, among others.

Lastly, using ranolazine with metformin may increase the risk of certain side effects. However, your doctor may decide that using both medications together is the best treatment option and may adjust the dosages accordingly. Always follow your healthcare provider's instructions and discuss any concerns you may have about drug interactions.