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Brexpiprazole is prescribed for the management of certain mental and mood disorders, including schizophrenia and depression. It is important to note specific safety concerns and precautions related to its use:

• Older Adults with Dementia: There is a slightly increased risk of severe, potentially life-threatening side effects, such as stroke, heart failure, irregular heartbeat, and pneumonia, when this medication is administered to elderly patients with dementia. Brexpiprazole is not approved for managing dementia-related behavioral issues without agitation, particularly those associated with Alzheimer’s disease. It is crucial to discuss these risks and benefits, as well as alternative treatments, with a healthcare provider.

• Use in Younger Individuals: While medications for depression, like Brexpiprazole, can reduce suicidal thoughts and provide significant benefits, studies indicate a small risk of worsening depression or emergence of suicidal thoughts, especially in individuals under the age of 25. It is essential to have an in-depth discussion with a healthcare provider about the risks and benefits of depression treatment, particularly for younger patients, even if the medication is prescribed for a non-mental health condition.

• Monitoring for Psychiatric Changes: Immediately inform a healthcare professional if there is a deterioration in depression symptoms, appearance of unusual behavioral changes, suicidal thoughts or attempts, or any new or worsening mental health symptoms. These include anxiety, panic attacks, sleep disturbances, irritability, aggressive feelings, impulsivity, extreme restlessness, or rapid speech. Close observation is especially critical when initiating treatment with a new antidepressant or adjusting the dosage.

Maintaining open communication with a healthcare provider and monitoring for any adverse changes can help ensure the safe use of Brexpiprazole.

Some common side effects of this medication include drowsiness, dizziness, lightheadedness, shaking, increased appetite, weight gain, restlessness, and an inability to keep still. These symptoms are generally mild, but if they persist or worsen, consult your healthcare provider.

This medication can sometimes cause a significant drop in blood pressure, particularly when starting or increasing the dosage. This might lead to dizziness or lightheadedness, heightening the risk of falls. To minimize this, rise slowly from sitting or lying positions.

While serious side effects are less common, be vigilant for symptoms such as trouble swallowing, fainting, or interrupted breathing during sleep. Additionally, unusual urges like increased gambling or sexual urges should be reported immediately.

Rarely, this drug may lead to a condition called tardive dyskinesia, which could be permanent. Look out for unusual or uncontrolled movements, especially in the face or limbs, and inform your doctor promptly.

An increase in blood sugar levels, potentially causing or worsening diabetes, can occur. Symptoms like increased thirst or urination should be addressed quickly. If you have diabetes, regular monitoring of blood sugar levels is advised.

Weight gain and elevated cholesterol or triglyceride levels may occur, increasing the risk of heart disease. Discuss any concerns with your healthcare provider.

The medication might also raise prolactin levels, leading to unwanted breast milk, menstrual changes, or fertility issues in females, and sexual dysfunction or breast enlargement in males. Report these symptoms to your healthcare provider without delay.

In rare instances, severe conditions like neuroleptic malignant syndrome or serious allergic reactions may occur. Symptoms such as fever, muscle stiffness, severe confusion, rash, or difficulty breathing require immediate medical attention. If you experience a seizure, seek urgent medical help.

This summary does not cover all possible side effects. Communicate with your healthcare provider about any other symptoms you experience.

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rephrased_text: A medication that may interact with this drug is Metoclopramide. Inform your doctor or pharmacist if you are using other products that can cause drowsiness. These include opioid painkillers or cough suppressants (like codeine or hydrocodone), alcohol, marijuana, sleep or anxiety medications (such as Alprazolam, Lorazepam, or Zolpidem), muscle relaxants (like Carisoprodol or Cyclobenzaprine), or antihistamines (such as Cetirizine or diphenhydramine). Be sure to check the labels of all your medications, including those for allergies or colds, as they might contain ingredients that induce drowsiness. Consult your pharmacist to ensure you are using these products safely.