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Brexpiprazole, a medication used to treat certain mental and mood disorders such as schizophrenia and depression, comes with several important safety warnings and precautions. It is crucial for patients and healthcare providers to be informed about these potential risks and to discuss them thoroughly before starting treatment. Below are the key safety considerations:

• Increased Risk for Older Adults with Dementia: Brexpiprazole should not be used for dementia-related psychosis due to a higher risk of fatal side effects, including heart problems, stroke, or infections. Discuss alternative treatments with your healthcare provider if dementia is a concern.

• Suicidal Thoughts and Behaviors: There is an increased risk of suicidal thoughts and behaviors in individuals, particularly those 24 years old or younger, when taking brexpiprazole or other antidepressants. Monitor for any mood changes, especially at the beginning of treatment or when adjusting the dosage, and report them to your healthcare provider immediately.

• Tardive Dyskinesia: This medication can cause tardive dyskinesia, characterized by uncontrollable muscle movements. The risk increases with higher dosages or prolonged use, particularly among older adults and females over 65. If you experience unusual movements, seek medical assistance.

• Neuroleptic Malignant Syndrome (NMS): Brexpiprazole can lead to a rare but potentially fatal condition known as NMS. Watch for symptoms such as high fever, muscle stiffness, confusion, and irregular heartbeat, and seek urgent medical care if they occur.

• Metabolic Changes: The medication may lead to high blood sugar, cholesterol levels, and weight gain. Patients with a history of diabetes or high cholesterol should closely monitor these conditions and report any symptoms like excessive hunger, thirst, or frequent urination to their provider.

• Impulsive Behavior: Brexpiprazole may cause impulsive behaviors, including gambling and excessive eating or shopping. Should these behaviors arise, consult with your healthcare provider about possible dosage adjustments or discontinuation.

• Infection Risk: This medication can lower white blood cell counts, increasing infection risk. Regular blood tests may be necessary to monitor cell counts. Report symptoms such as fever, weakness, or sore throat to your provider.

• Fall Risk: Brexpiprazole might cause dizziness or low blood pressure, leading to falls. Stand or sit up slowly to mitigate this risk, especially when starting the medication or increasing the dose.

• Seizure Risk: Individuals with a history of seizures or conditions predisposing them to seizures should exercise caution and discuss their medical history with their provider before starting brexpiprazole.

In case of an overdose or severe side effects, seek immediate medical attention. Always consult with your healthcare provider regarding potential interactions with other medications or substances. This comprehensive awareness can ensure safer and more effective use of brexpiprazole.

When taking this medication, some common side effects may occur, but they are generally mild. These include drowsiness, dizziness, lightheadedness, increased appetite, and weight gain. You might also experience restlessness, inability to keep still, fidgeting, headaches, sleepiness, tremors, and common cold symptoms. Other mild symptoms can include fatigue, anxiety, heartburn, diarrhea, constipation, blurry vision, nausea, dry mouth, stomach pain, and muscle pain. If these effects become bothersome or persist, consult your healthcare provider.

In some cases, this medication may cause more serious side effects that require prompt medical attention. These include trouble swallowing, fainting, interrupted breathing during sleep, and unusual urges like increased gambling or sexual impulses. It can rarely cause a condition called tardive dyskinesia, marked by uncontrolled movements of the face and limbs. Additionally, the medication may lead to high blood sugar levels, which can exacerbate diabetes. Symptoms to watch for include increased thirst or urination. There is also a potential for weight gain and higher cholesterol, which may heighten heart disease risks.

In rare instances, the medication might elevate prolactin levels, causing unwanted breast milk in females or decreased sexual ability in males. Seek medical help if you experience seizures or symptoms of neuroleptic malignant syndrome, such as fever, muscle stiffness, confusion, or irregular heartbeat. An allergic reaction is also rare but serious, with symptoms including rash, swelling, or trouble breathing. Always report any unexpected effects to your healthcare provider for guidance.