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Perphenazine-amitriptyline

Perphenazine-amitriptyline Coupons & Discount Card - Compare Prices Near You

Perphenazine/amitriptyline is a combination medication designed to treat depression associated with other mental health conditions such as anxiety and schizophrenia. This medication integrates two active components: perphenazine, a typical antipsychotic, and amitriptyline, a tricyclic antidepressant. The drug works by helping to restore the balance of certain natural substances in the brain, improving mood and reducing anxiety. It is typically prescribed for moderate-to-severe anxiety and depression, as well as schizophrenia with depressive symptoms. The medication is taken orally in tablet form, usually three or four times a day. Common side effects may include sleepiness, dizziness, and dry mouth, while more serious risks could involve thoughts of suicide and low blood cell counts. As with any medication, consult with a healthcare professional before use to ensure it is suitable for your specific condition.
Our coupons are free to use. Before paying, show the pharmacist your Perphenazine-amitriptyline savings card to get your free discount. Use our filters below to edit the prescription box to match your needs. The Perphenazine-amitriptyline prices will update based on your prescription needs. Above our Perphenazine-amitriptyline coupons, you can change your location to see pharmacy prices and costs in other areas. We're here to help you buy Perphenazine-amitriptyline at the lowest price with our prescription discount card.

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2-10MG, Perphenazine-amitriptyline (30 Tablets)

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CVS

$26.82

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Walgreens

$17.27

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Walmart

$20.85

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Rite Aid

$40.99

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Albertsons

$48.19

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Perphenazine-amitriptyline savings card

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CVS

$26.82

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Perphenazine-amitriptyline dosage forms

The average cost for 30 Tablets of Perphenazine-amitriptyline at 2-10MG is $20.85 with a free coupon. This is 19.14% off the average retail price of $108.96
DosageQuantityPrice fromPer unit
2-10MG30 Tablets$20.85$0.7
2-25MG30 Tablets$31.74$1.06
4-10MG30 Tablets$25.59$0.85
4-25MG30 Tablets$32.46$1.08
4-50MG30 Tablets$32.46$1.08

Perphenazine-amitriptyline Warnings

Antidepressants, such as perphenazine/amitriptyline, are commonly prescribed for treating depression and other mental health disorders. While these medications offer significant benefits, they also pose certain risks. Below are important safety warnings and precautions to consider:

  • Increased Risk for Younger Users: Individuals under 25 years old may experience worsening depression, increased suicidal thoughts, or unusual behavioral changes, particularly when starting treatment or adjusting the dose.
  • Risks for Older Adults with Dementia: Older adults, particularly those over 65 with dementia-related psychosis, are at a higher risk of serious side effects and increased mortality when using these medications.
  • Bipolar Disorder Precaution: Antidepressants should not be used alone in individuals with bipolar disorder, as they may trigger manic episodes.
  • Movement Disorders: Long-term or high-dose use can lead to movement problems such as involuntary twitching, more common in older females.
  • Neuroleptic Malignant Syndrome (NMS): This rare but serious condition requires immediate medical attention if symptoms like high fever, muscle stiffness, or confusion occur.
  • Fall Risk: The medication may cause drowsiness and low blood pressure, increasing the risk of falls, especially in older adults.
  • Blood Cell Count Issues: There is a potential for reduced white blood cell counts, increasing infection risk, particularly in those with pre-existing conditions.
  • Cardiovascular Concerns: High doses may lead to heart rhythm problems, stroke, or heart attack.
  • Seizure Risk: Those with a history of seizures should consult their doctor, as the medication may elevate seizure risk.
  • Glaucoma: The medication can worsen angle-closure glaucoma, so any vision changes should be reported.

Contraindications:

  • Avoid use if experiencing slowed brain activity due to sedatives or similar substances.
  • Not recommended for individuals with recent heart attacks, low blood cell counts, or those who have recently used MAOIs.

In case of overdose or severe side effects, seek emergency medical assistance immediately. Always discuss the risks and benefits of this medication with your healthcare provider to determine the most appropriate treatment plan.

Perphenazine-amitriptyline Side Effects

Common side effects:

  • drowsiness
  • dizziness
  • dry mouth
  • blurred vision
  • constipation
  • tiredness

Less common but important to monitor:

  • headaches
  • nausea
  • vomiting
  • sweating
  • itching
  • skin rash
  • changes in weight
  • restlessness
  • tremors
  • uncontrolled body movements
  • unwanted breast milk production
  • menstrual changes
  • decreased sexual ability

Serious side effects:

  • muscle stiffness
  • severe confusion
  • rapid heartbeat
  • dark urine
  • signs of a stroke
  • chest pain
  • irregular heartbeat
  • tardive dyskinesia
  • neuroleptic malignant syndrome
  • serious allergic reaction

Perphenazine-amitriptyline Interactions

Interactions with high risk of serious adverse effects and should be avoided:

  • MAO inhibitors (isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine)
  • Bepridil
  • Cisapride
  • Dronedarone
  • Droperidol
  • Grepafloxacin
  • Furazolidone
  • Mesoridazine
  • Pimozide
  • Piperaquine
  • Ranolazine
  • Sparfloxacin
  • Terfenadine
  • Thioridazine
  • Ziprasidone

Interactions with moderate risk that may require dose adjustment, closer monitoring, or timing changes:

  • Amiodarone
  • Quinidine
  • Erythromycin
  • Ketoconazole
  • Fluoxetine
  • Paroxetine
  • Cimetidine
  • Rifamycins
  • Anti-HIV drugs
  • Aspirin
  • Nortriptyline

Interactions with low risk that usually do not require a change in therapy:

  • Alcohol
  • Marijuana (cannabis)
  • Alprazolam
  • Lorazepam
  • Zolpidem
  • Cetirizine
  • Diphenhydramine
  • Codeine
  • Hydrocodone
Perphenazine-amitriptyline FAQs
What is perphenazine amitriptyline used for?

Perphenazine amitriptyline is a combination medication used to treat symptoms of depression and anxiety. It combines perphenazine, an antipsychotic, with amitriptyline, a tricyclic antidepressant, to help manage mood disorders.

Amitriptyline is still used today, but its use has declined for certain conditions due to the development of newer medications with fewer side effects. It is a tricyclic antidepressant that can be effective for depression, chronic pain, and certain types of headaches. However, newer antidepressants, such as SSRIs and SNRIs, are often preferred because they generally have a more favorable side effect profile. Despite this, amitriptyline remains a valuable option for some patients, particularly when other treatments are not effective.

Yes, amitriptyline can cause weight gain as a side effect. This is a common occurrence with tricyclic antidepressants, and patients may experience an increase in appetite or changes in metabolism that contribute to weight gain. It is important for patients to discuss any concerns about weight changes with their healthcare provider.

Perphenazine works by affecting the balance of certain natural chemicals, or neurotransmitters, in the brain. It primarily blocks dopamine receptors, which can help reduce symptoms of psychosis such as hallucinations and delusions. By modulating these neurotransmitter levels, perphenazine can help stabilize mood and improve thought processes in individuals with certain psychiatric conditions.

Amitriptyline is most commonly used for the treatment of depression. It is a tricyclic antidepressant that can also be prescribed for other conditions such as chronic pain, migraine prevention, and certain types of nerve pain.