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Below is the safety and warning information related to the use of Semglee (insulin glargine). Please read these details carefully and discuss any concerns with your healthcare provider.

• Infection Risk: Do not share Semglee (insulin glargine) pens, syringes, or needles with others, as it can lead to serious infections like HIV and hepatitis B.

• Blood Sugar Level Changes: Alterations in your insulin regimen, including the injection site or switching to a biosimilar, can impact blood sugar levels, causing them to rise or fall. Injecting into areas with lipodystrophy can lead to elevated blood sugar.

• Hypoglycemia: Using Semglee alone or with other blood sugar-lowering medications can result in dangerously low blood sugar (hypoglycemia). Factors increasing this risk include dietary changes, alcohol intake, additional diabetes medications, liver or kidney issues, and improper use of Semglee.

• Low Potassium Levels: Semglee may decrease potassium levels in your blood, which can be serious. This risk is higher if you're on medications that also reduce potassium, like loop diuretics. Regular blood tests may be necessary to monitor your potassium levels. Seek immediate medical attention if you experience symptoms such as weakness, muscle cramps, or constipation.

• Fluid Retention and Heart Failure: Combining Semglee with glitazones can cause fluid retention, worsening heart failure symptoms like shortness of breath, swelling, and fatigue. This combination is particularly risky for those with heart failure.

• Severe Allergic Reactions: Though uncommon, Semglee can cause severe allergic reactions, including anaphylaxis. If you have swelling of the lips, face, or tongue, a rash, or difficulty breathing, seek emergency medical help.

Contraindications: Do not use Semglee if you are experiencing episodes of hypoglycemia. Consult your healthcare provider for guidance.

These warnings are crucial for your safety while using Semglee. Always follow your healthcare provider's instructions and report any adverse effects promptly.

When taking this medication, you may experience some common side effects, which are generally mild and include upper respiratory tract infections, swelling in the hands or feet, high blood pressure, flu-like symptoms, sinus infections, bronchitis, cataracts, joint pain, and pain in the hands or feet. Other common issues may be back pain, cough, urinary tract infections, diarrhea, depression, and headaches. If these symptoms continue or worsen, it is advisable to consult your healthcare provider for guidance.

In some cases, this medication can cause low blood sugar, known as hypoglycemia. Symptoms of hypoglycemia include sudden sweating, shaking, a rapid heartbeat, hunger, blurred vision, dizziness, or tingling in the hands or feet. To manage low blood sugar, it is helpful to carry glucose tablets or gel, or consume quick sources of sugar like table sugar, honey, or candy. Regular meals and not skipping them can help prevent these occurrences. On the other hand, symptoms of high blood sugar, or hyperglycemia, include increased thirst and urination, and should also be reported to your doctor.

While rare, there are serious side effects such as dangerously low blood sugar, which can lead to unconsciousness or seizures if untreated, and severe allergic reactions characterized by breathing difficulties, rash, or swelling of the face, mouth, or throat. Another serious concern is low potassium levels, which may cause muscle cramps, weakness, irregular heartbeat, or kidney issues. If you experience any severe symptoms, seek medical attention immediately. Always report any side effects to your healthcare provider for proper management.