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This medication comes with important safety warnings that you should carefully review. Please consult your healthcare provider if you have any concerns or questions regarding its use.

• Infection Risk from Shared Supplies: Never share Humalog (insulin lispro) pens, syringes, needles, or cartridges with others. Sharing injection supplies can significantly increase the risk of transmitting severe infections.

• Risk of Hypoglycemia (Low Blood Sugar): Using Humalog (insulin lispro) alone or with other diabetes medications may cause dangerously low blood sugar levels. This risk is heightened by changes in diet or exercise, transitioning from a different insulin type, alcohol consumption, concurrent use of other diabetes medications, or existing liver or kidney issues. Always verify that you are using the correct insulin and monitor your blood sugar levels.

• Low Blood Potassium Levels: Humalog (insulin lispro) may lead to decreased potassium levels, which can be harmful. This is particularly concerning if you are taking medications like certain diuretics that also reduce potassium. Regular monitoring of potassium levels by your healthcare provider is advised. Report symptoms such as weakness, muscle cramps, nausea, vomiting, or irregular heartbeats promptly.

• Fluid Retention and Heart Failure Risk: Concurrent use of Humalog (insulin lispro) with glitazones (e.g., pioglitazone) can lead to fluid retention, exacerbating or causing heart failure. Notify your provider if you experience sudden weight gain or heart failure symptoms like breathing difficulties, fatigue, or headaches. Medication adjustments may be necessary.

• High Blood Sugar and Ketoacidosis: For insulin pump users, ensure your pump is functioning correctly. Malfunctioning pumps can lead to high blood sugar or ketoacidosis, a severe diabetes complication. Seek immediate medical advice if your pump fails and inject Humalog (insulin lispro) via alternative methods if advised. Symptoms of ketoacidosis, such as fatigue, fruity breath, or vomiting, should be reported to your healthcare provider without delay.

Contraindications:

• Do Not Use During Hypoglycemia: Avoid using this medication if you are experiencing low blood sugar levels, as it may pose serious health risks. Always consult your healthcare provider in these instances.

When using this medication, some common side effects may occur but are usually mild and manageable. These include flu-like symptoms, sore throat, runny nose, headache, general pain, cough, and infection. If these effects persist or worsen, it is advisable to consult your healthcare provider for guidance.

More serious side effects, although less common, should be taken seriously. Notable among these are weight gain, swelling, and reactions at the injection site, such as redness, swelling, and itching. Immediate medical attention is necessary if these symptoms appear.

This medication can also affect blood sugar levels. Low blood sugar (hypoglycemia) might manifest as sudden sweating, shaking, a fast heartbeat, hunger, blurred vision, dizziness, or tingling in the hands and feet. To address this, carrying glucose tablets or a quick sugar source is beneficial. Conversely, high blood sugar (hyperglycemia) may cause increased thirst and urination. Promptly inform your doctor about these symptoms, as adjustments to your medication, diet, or exercise may be needed.

In rare cases, a serious allergic reaction may occur, characterized by rash, itching, swelling of the face, tongue, or throat, severe dizziness, and trouble breathing. Seek emergency medical help immediately if you experience these symptoms. Always stay informed about your health and communicate any side effects not listed here with your healthcare provider.

Humalog (insulin lispro) can interact with various medications and supplements, which may affect your treatment plan. Always inform your doctor and pharmacist about all the medications you are taking, including prescription, over-the-counter drugs, vitamins, and herbal supplements.

Potential Interactions:

1. Medications Typically Not Recommended Together:

   • Some medications, like certain antibiotics (e.g., Ciprofloxacin, Levofloxacin) and other drugs (e.g., Hydroxychloroquine, Liraglutide), may not be recommended for use with Humalog. In situations where using both is necessary, your healthcare provider might adjust the dosage or usage frequency of one or both medications.

2. Medications That May Increase Side Effects:

   • Combining Humalog with other medications, including certain beta-blockers (e.g., Metoprolol, Propranolol) and drugs for mental health or blood pressure (e.g., Phenelzine, Carvedilol), may heighten the risk of side effects. However, using these medications together might be the most effective treatment option for you. In such cases, your doctor might modify the dosage or frequency of use.

Important Considerations:

• Beta-blockers, like Metoprolol and Propranolol, might mask the symptoms of low blood sugar, such as a rapid heartbeat, but do not affect other symptoms like dizziness or sweating. This can complicate the management of blood sugar levels.
• Regular monitoring of your blood sugar is crucial. Discuss any fluctuations or symptoms of high or low blood sugar with your doctor, who may need to adjust your diabetes medication, exercise regimen, or diet accordingly.
• Insulin lispro and insulin lispro-aabc are very similar; therefore, they should not be used concurrently.

Always consult your healthcare provider before starting, stopping, or changing any medication to ensure safe and effective management of your health condition.