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The safety and warning information provided below is crucial for understanding the potential risks and precautions associated with this medication. Please read carefully and discuss any concerns with your healthcare provider.

• Medication Interactions: Inform your healthcare provider or pharmacist about all medications and supplements you are currently taking before beginning treatment with norethindrone. This allows them to identify any potential interactions.

• Ectopic Pregnancy or Ovarian Cyst: If pregnancy occurs while taking norethindrone, there is a slight risk it could be ectopic, meaning it develops outside the womb. This is a serious condition requiring immediate medical attention. Watch for symptoms such as cramping or pain in the lower abdomen or shoulder and seek medical help promptly.

• Irregular Vaginal Bleeding: This is a common side effect of progestin-only pills (POPs) like norethindrone. Occasionally, it may indicate a more serious issue, such as an infection or cancer. If you experience irregular bleeding or have concerns, consult your healthcare provider. Additionally, if there is an absence of vaginal bleeding, it is advisable to check with your provider to confirm pregnancy status.

• Possible Risk of Cancer: Some studies suggest a potential increase in the risk of breast or ovarian cancer associated with combination birth control pills. However, it is unclear if norethindrone or other POPs carry the same risk. Discuss any concerns about cancer risk with your provider.

Contraindications: This medication should not be used under the following conditions due to the potential for serious health risks. Consult your healthcare provider if any of these apply to you:

• Current or suspected pregnancy
• Confirmed or suspected breast cancer
• Unexplained bleeding between periods
• Liver tumors, whether benign or cancerous
• Acute liver disease

Ensure you adhere to all precautions and consult with your healthcare provider to safely manage your treatment with norethindrone.

When taking this medication, you might experience some common side effects such as nausea, vomiting, headaches, dizziness, bloating, and breast tenderness. You may also notice changes in your menstrual cycle, including irregular periods or spotting. These effects are generally mild and should not cause undue concern, but if they persist or worsen, it’s advisable to consult with your healthcare provider.

More serious side effects are rare, but they do require immediate medical attention. These include the development of lumps in the breast, significant mood changes like new or worsening depression, severe stomach or abdominal pain, and unusual changes in vaginal bleeding, such as continuous spotting, sudden heavy bleeding, or missed periods. Additionally, signs of liver issues, such as dark urine or yellowing of the eyes and skin, should be addressed promptly.

An ectopic pregnancy, although infrequent, is a critical condition indicated by symptoms like severe stomach pain and spotting. If you suspect this, seek urgent medical care. Moreover, although a severe allergic reaction is rare, symptoms like rash, itching or swelling of the face, tongue, or throat, severe dizziness, and trouble breathing warrant immediate medical help. Always monitor how your body responds to the medication and communicate any concerns to your healthcare provider.