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When taking Loryna, a hormonal birth control, it is crucial to be aware of potential risks and necessary precautions. Review the following safety information carefully and consult your healthcare provider if you have any concerns.

• Smoking and Heart Problems: Smoking while using Loryna can significantly increase the risk of blood clots, potentially leading to serious conditions like heart attacks or strokes. This risk is especially high for individuals over 35 who smoke. Discuss safer birth control alternatives with your healthcare provider if you smoke.

• Blood Clot Risk: Loryna, containing ethinyl estradiol, can elevate the risk of blood clots. This risk is higher for those over 35, smokers, individuals with recent surgeries requiring bed rest, or those starting Loryna shortly after childbirth. Seek immediate medical attention if you experience symptoms of a blood clot.

• High Potassium Levels: Drospirenone in Loryna can increase potassium levels. If you have kidney, liver, or adrenal issues, or are taking medications that raise potassium, your doctor may monitor your potassium levels. Report symptoms like nausea, irregular heartbeat, or muscle weakness.

• Cancer Risk: While studies vary, Loryna may slightly increase the risk of breast and cervical cancer. Those with a history of these cancers or long-term use should discuss options with their healthcare provider.

• Liver Issues: Avoid Loryna if you have liver problems. This medication may increase the risk of benign liver tumors. Discontinue use and consult your healthcare provider if you notice symptoms like jaundice or dark urine.

• Gallbladder Concerns: Loryna may increase the risk of gallbladder disease in some individuals. Those with a history of gallbladder issues should talk to their healthcare provider before starting the medication.

• High Blood Pressure: Loryna can elevate blood pressure, especially in older individuals or those using hormonal contraceptives long-term. If you have a history of high blood pressure, ensure it is monitored while using Loryna.

• Blood Sugar and Triglycerides: Loryna can raise blood sugar and triglyceride levels. Individuals with prediabetes, diabetes, or high triglycerides should have these levels monitored and consider alternative birth control options.

• Headaches: Report any new or worsening headaches, including migraines, to your healthcare provider, as this may require discontinuation of the medication.

• Irregular Bleeding: Irregular bleeding is common in the first three months of Loryna use. If bleeding persists, becomes heavier, or if you miss a period, contact your healthcare provider.

• Depression: If you have a history of depression, monitor mood changes while using Loryna. Inform your healthcare provider if symptoms worsen.

• Worsening Health Conditions: Discuss with your healthcare provider if you have hereditary angioedema or chloasma, as Loryna may exacerbate these conditions. Limit sun exposure if you have a history of chloasma.

Contraindications: Do not use Loryna if you have:

• Kidney or adrenal gland issues.
• A high risk of blood clots.
• A history of blood clots, stroke, or heart attack.
• Are over 35 and smoke.
• Uncontrolled high blood pressure.
• Diabetes with complications.
• Migraines with aura or any migraines if over 35.
• BMI of 30 kg/m² or higher.
• Liver disease.
• Are pregnant or have unexplained vaginal bleeding.
• A history of breast cancer.
• Take specific hepatitis C treatments.

Consult your healthcare provider for personalized advice and alternatives if any of these apply to you.

When taking this medication, some individuals may experience mild side effects such as headaches, nausea, vomiting, breast tenderness, bloating, or swelling of the ankles and feet due to fluid retention. Weight changes, tiredness, and irregular menstrual bleeding, including spotting or missed periods, are also common. These side effects are generally mild and should not cause alarm, but if they persist or worsen, consulting a healthcare provider is advisable.

It is important to be aware of potential serious side effects, though they are rare. These include mood changes, irritability, and a decrease in sex drive. More severe reactions, such as high blood pressure, unusual changes in vaginal bleeding, or symptoms indicating high potassium levels, require prompt medical attention. Additionally, this medication may increase the risk of blood clots, which can lead to heart attacks, strokes, or clots in the lungs or legs. Immediate medical help should be sought if you experience symptoms like sudden severe headaches, chest pain, shortness of breath, or any signs of an allergic reaction like rash, swelling, or difficulty breathing.

Finally, if you experience serious symptoms such as lumps in the breast, severe abdominal pain, dark urine, yellowing of the eyes or skin, or mental changes such as depression or suicidal thoughts, seek urgent medical care. Always inform your healthcare provider of any side effects you encounter, as this can help manage your treatment effectively.

When taking Loryna, it's important to be aware of potential drug interactions. Certain medications and supplements can affect how Loryna works, so always inform your healthcare provider about everything you're taking, including prescription, over-the-counter, vitamins, and herbal products.

Some medications should not be combined with Loryna, as they can cause significant interactions. These include boceprevir, dasabuvir, ombitasvir, paritaprevir, Ritonavir, and Tranexamic Acid. Your doctor might choose an alternative treatment if you're using any of these.

Other medications may require careful monitoring and dose adjustments if used with Loryna. These include amifampridine, Amoxicillin, Ampicillin, Carbamazepine, griseofulvin, Modafinil, Rifampin, and St. John's wort, among others. These drugs might reduce the effectiveness of Loryna by decreasing hormone levels, possibly leading to an increased risk of pregnancy. Therefore, you may need to use additional contraceptive methods.

Loryna can also raise potassium levels, so caution is advised if you're taking drugs like Aliskiren, ACE inhibitors (e.g., enalapril, Lisinopril), angiotensin receptor blockers (e.g., Losartan, Valsartan), NSAIDs (e.g., Ibuprofen, Naproxen), and potassium-sparing diuretics (e.g., Spironolactone, Triamterene).

Additionally, Loryna might interfere with certain lab tests, resulting in inaccurate results. Ensure all healthcare professionals involved in your care know that you are using this medication. Always discuss any new medications or changes in your regimen with your doctor to avoid potential complications.