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Esketamine is administered in a controlled medical setting, such as a doctor's office or clinic. This medication may lead to drowsiness, dizziness, fainting, anxiety, or significantly reduced breathing, which could be life-threatening. Additionally, it might cause feelings of detachment from one’s body, thoughts, emotions, surroundings, and time. As a safety precaution, patients must be observed by a healthcare provider for a minimum of two hours post-treatment to ensure that side effects subside before leaving the facility.

Important Safety Information:

• Esketamine carries a risk of misuse and both physical and psychological dependence. For further details, refer to the How to Use section.
• In the United States, patients must comply with the REMS Program requirements specific to esketamine. For regulations in Canada or other countries, consult with local healthcare professionals.
• Antidepressants, including esketamine, are prescribed for treating depression and other mental health conditions. They can prevent suicidal thoughts or attempts and offer critical benefits. However, some individuals, particularly those under 25, may experience an increase in depression, other psychiatric symptoms, or suicidal thoughts. Discussing these risks and benefits with a healthcare provider is crucial, especially for individuals under 25 or those using the medication for non-psychiatric reasons.
• Immediately inform a healthcare provider if there are signs of worsening depression or other psychiatric conditions, unusual behavioral changes, or mental health symptoms such as new or worsening anxiety, panic attacks, insomnia, irritability, hostility, impulsivity, severe restlessness, or excessively rapid speech. These symptoms warrant close observation, particularly when beginning a new antidepressant or adjusting the dosage.

By adhering to these guidelines and maintaining open communication with healthcare professionals, patients can safely manage their treatment with esketamine.

When taking this medication, you might experience some common side effects like feeling dizzy, drowsy, tired, or nauseous, as well as a sensation of spinning or reduced sensitivity to touch. These effects are generally mild, but if they persist or worsen, consult your healthcare provider.

It's important to note that while many people do not experience severe side effects, you should be vigilant about certain symptoms. Report immediately if you experience increased nighttime urination, pain or burning during urination, or an urgent need to urinate frequently. This medication can also cause a temporary increase in blood pressure, lasting about four hours after a dose. Blood pressure will be monitored by your healthcare provider before and after taking the medication.

More serious reactions, though rare, require immediate medical intervention. Seek help if you experience chest pain, difficulty breathing, a sudden severe headache, changes in vision, seizures, or loss of consciousness. Additionally, though uncommon, a serious allergic reaction may occur. Look out for symptoms such as rash, severe dizziness, swelling of the face, tongue, or throat, and difficulty breathing.

This list does not include all possible side effects. If you notice any other unusual effects, reach out to your healthcare provider for further guidance.