Methotrexate

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generic Xatmep, Reditrex, Jylamvo

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1GM of 1, Methotrexate (1 Bottle)

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CVS

$331.65

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Rite Aid

$308.49

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Walmart

$311.87

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Walgreens

$322.86

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Methotrexate savings card

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CVS

$331.65

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Methotrexate dosage forms

The average cost for 1 Bottle of Methotrexate (generic Xatmep, Reditrex, Jylamvo) at 1GM of 1 is $311.87 with a free coupon. This is 27.35% off the average retail price of $1140.2
DosageQuantityPrice fromPer unit
1GM of 11 Bottle$311.87$311.87

Methotrexate Warnings

Below is a rephrased version of critical safety and warning information for methotrexate. Please read carefully and consult your healthcare provider with any questions or concerns.

  • Risk to Unborn Babies: Methotrexate poses a significant risk to unborn children, potentially causing harm or miscarriage. Therefore, it is contraindicated for non-cancer conditions during pregnancy.

  • Allergic Reactions: Some individuals may experience allergic reactions, including symptoms like itching, fever, nausea, difficulty breathing, or a rapid heartbeat. Seek immediate medical attention if symptoms of anaphylaxis, such as hives, facial swelling, or throat tightness, occur.

  • Preservative Concerns: Certain methotrexate injections contain benzyl alcohol, which can be harmful, particularly to newborns, individuals receiving high doses, or those undergoing intrathecal injections. These groups should avoid benzyl alcohol-containing formulations due to potential neurological risks.

  • Blood Cell Count Reduction: Methotrexate may lead to decreased blood cell counts, elevating the risk of fatigue, bleeding, and infections, especially at cancer treatment dosages.

  • Infection Risk: The medication increases susceptibility to infections, including opportunistic infections. Preventative treatments, like antibiotics, might be prescribed based on your condition and concurrent medications. Contact your provider promptly if you exhibit symptoms such as fever, severe fatigue, or respiratory difficulties.

  • Kidney Damage: The drug can potentially damage the kidneys, with an increased risk for those with pre-existing kidney issues or on high-dose methotrexate. Regular monitoring of kidney function is essential, and protective measures such as intravenous hydration may be recommended.

  • Liver Damage: Although rare, methotrexate can cause liver issues, including cirrhosis or liver failure. Discuss the risks and benefits with your provider if you have liver concerns, particularly with heavy alcohol consumption.

  • Nervous System Complications: Serious conditions like seizures, vision changes, or coma can occur, especially with high doses or intrathecal injections. Past brain radiation therapy may elevate this risk.

  • Gastrointestinal Issues: Methotrexate can cause digestive tract damage, leading to symptoms like vomiting or stomach bleeding. Immediate care is required for sudden abdominal pain or bloody stools.

  • Lung Issues: Some users develop interstitial lung disease, a serious condition that can be life-threatening. Report new or worsening respiratory symptoms to your provider at once.

  • Severe Skin Reactions: Serious skin conditions, such as Stevens-Johnson syndrome, may develop. Notify your provider immediately if blisters or skin peeling occurs.

  • Folic Acid Levels: Methotrexate reduces folic acid in the body, critical for cell growth. Avoid folic acid supplements when using methotrexate for cancer treatment, as they can reduce the drug's effectiveness.

  • Potential New Cancers: Rarely, methotrexate use has been linked to the development of new cancers, especially in the white blood cells.

  • Tumor Lysis Syndrome: This potentially dangerous condition can occur with cancer treatment, leading to elevated uric acid and potassium levels.

  • Infertility Risks: Methotrexate might affect fertility, causing issues like low sperm count or menstrual problems. Discuss fertility preservation with your provider if future family planning is a concern.

  • Radiation Therapy Risks: When combined with radiation treatment, methotrexate may increase the risk of tissue and bone damage.

  • Fluid Retention Concerns: Methotrexate can accumulate in body fluids, prolonging its presence and increasing side effects. Your provider will monitor and manage any fluid buildup.

  • Dosing Errors: Methotrexate dosages vary significantly between cancer and non-cancer uses. Incorrect dosing can lead to severe side effects, emphasizing the need for careful adherence to prescribed amounts.

Contraindications:

  • Do not use methotrexate if you have had a severe allergic reaction to it.
  • Pregnant individuals should not take methotrexate for non-cancer conditions.

Always discuss any health conditions or concerns with your healthcare provider before starting methotrexate.

Methotrexate Side Effects

Common side effects:

  • Mouth sores
  • Nausea or vomiting
  • Diarrhea
  • Stomach pain
  • Tiredness
  • Dizziness
  • Chills
  • Fever

Less common but important to monitor:

  • Infections
  • Elevated liver enzymes
  • Low white blood cell counts
  • Low platelet levels

Serious side effects:

  • Serious infections due to low white blood cell counts
  • Blood in urine or stool
  • Nosebleeds
  • Unexplained or persistent bruising or bleeding
  • Severe lung problems
  • Serious liver issues
  • Nervous system complications
  • Serious skin reactions
  • Allergic reaction

Methotrexate Interactions

Some products that may interact with this drug include: acitretin, asparaginase, leflunomide, other drugs that can cause kidney problems (such as cisplatin), other drugs that can cause liver problems (such as azathioprine, sulfasalazine, retinoids such as isotretinoin), penicillins, phenytoin, probenecid, procarbazine, pyrimethamine, sulfa medications, tetracyclines. Certain drugs that reduce stomach acid (proton pump inhibitors-PPIs such as esomeprazole, omeprazole, pantoprazole) may increase the amount of methotrexate in your blood. This effect may increase the risk of side effects, especially with high-dose methotrexate treatment. Ask your doctor or pharmacist for details and ways to lessen the risk of side effects.
Methotrexate FAQs
What exactly does methotrexate do?

Methotrexate is a medication that interferes with the growth of certain cells in the body, particularly those that reproduce quickly, such as cancer cells, bone marrow cells, and skin cells. It is commonly used to treat certain types of cancer, severe psoriasis, and rheumatoid arthritis by reducing inflammation and suppressing the immune system.

The most common side effect of methotrexate is gastrointestinal upset, which can include nausea and vomiting.

When taking methotrexate, it is advisable to avoid foods that are high in folic acid, as methotrexate can interfere with folic acid metabolism. This includes foods like leafy green vegetables, fortified cereals, and certain beans. Additionally, alcohol should be avoided or limited, as it can increase the risk of liver damage when combined with methotrexate. It is important to consult with a healthcare provider for personalized dietary recommendations.

Methotrexate is commonly used to treat several autoimmune diseases, including rheumatoid arthritis, psoriasis, and psoriatic arthritis. It is also used in the management of other conditions such as systemic lupus erythematosus and certain types of vasculitis.

The decision to use methotrexate should be made in consultation with a healthcare provider, who can weigh the potential benefits against the risks for the individual's specific condition. Methotrexate is commonly used to treat certain types of cancer, rheumatoid arthritis, and psoriasis, and it can be very effective. However, it does come with potential side effects, including liver damage, lung issues, and bone marrow suppression. Regular monitoring and follow-up with a healthcare provider are essential to manage these risks effectively.